ArticleBehavioral neuroscience2014
Once is too much: conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats.
Article in Behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Effect of acute treatment with the glucagon-like peptide-1 receptor agonist, liraglutide, and estrus phase on cue- and drug-induced fentanyl seeking in female rats.Behavioural pharmacology · 2025Article
- Dose titration with the glucagon-like peptide-1 agonist, liraglutide, reduces cue- and drug-induced heroin seeking in high drug-taking rats.Brain research bulletin · 2022Review
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Emergence of negative affect as motivation for drug taking in rats chronically self-administering cocaine.Psychopharmacology · 2020Article
- Drug-induced dysphoria is enhanced following prolonged cocaine abstinence and dynamically tracked by nucleus accumbens neurons.Addiction biology · 2019Article
- Conditioned aversive responses produced by delayed, but not immediate, exposure to cocaine and morphine in male Sprague-Dawley rats.Psychopharmacology · 2018Article
- A Neuronal Ensemble in the Rostral Agranular Insula Tracks Cocaine-Induced Devaluation of Natural Reward and Predicts Cocaine Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Once is too much: Early development of the opponent process in taste reactivity behavior is associated with later escalation of cocaine self-administration in rats.Brain research bulletin · 2018Article
- Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation 'bath salt' α-pyrrolidinopentiophenone (α-PVP).Pharmacology, biochemistry, and behavior · 2017Article
- Conditioned taste aversions: From poisons to pain to drugs of abuse.Psychonomic bulletin & review · 2017Article
- Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability.Drug and alcohol dependence · 2016Article
- The role of dose and restriction state on morphine-, cocaine-, and LiCl-induced suppression of saccharin intake: A comprehensive analysis.Physiology & behavior · 2016Article
- Drug-motivated behavior in rats with lesions of the thalamic orosensory area.Behavioral neuroscience · 2016Article
- Low expression of D2R and Wntless correlates with high motivation for heroin.Behavioral neuroscience · 2015Article
- Drug predictive cues activate aversion-sensitive striatal neurons that encode drug seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Food reward system: current perspectives and future research needs.Nutrition reviews · 2015Review
- Conditioned Aversion for a Cocaine-Predictive Cue is Associated with Cocaine Seeking and Taking in Rats.International journal of comparative psychologyArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial basis in an effort to determine when the change in behavior occurs and whether early changes in this behavior can be used to predict later drug taking. The results show that conditioned aversive TR to a cocaine-paired cue occurs very early in training (i.e., following as few as 1-2 taste-drug pairings) and, importantly, that it can be used to predict later drug seeking and drug taking in rats.
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