ArticleJournal of diabetes research2014
The cytotoxic role of intermittent high glucose on apoptosis and cell viability in pancreatic beta cells.
Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- The paracrine signalling between endothelial and pancreatic β-cells: implications for oxidative stress and diabetes.Journal of endocrinological investigation · 2026Review
- Role of oxidative stress in prediabetes development.Biochemistry and biophysics reports · 2025Review
- Lipoic acid-plumbagin conjugate protects pancreatic beta cells against high glucose-induced toxicity.Scientific reports · 2025Article
- Metabolic, genetic and immunological features of relatives of type 1 diabetes patients with elevated insulin resistance.Journal of endocrinological investigation · 2025Article
- The Emerging Role of p21 in Diabetes and Related Metabolic Disorders.International journal of molecular sciences · 2024Review
- Association of xanthine oxidoreductase inhibitor use with insulin secretory capacity in patients with type 2 diabetes.Journal of diabetes investigation · 2024Article
- Glucose Variability: How Does It Work?International journal of molecular sciences · 2021Review
- Redox Homeostasis in Pancreatic β-Cells: From Development to Failure.Antioxidants (Basel, Switzerland) · 2021Review
- MiR-17-5p Inhibits TXNIP/NLRP3 Inflammasome Pathway and Suppresses Pancreatic β-Cell Pyroptosis in Diabetic Mice.Frontiers in cardiovascular medicine · 2021Article
- Insulin Autoimmune Syndrome as Part of Pre-Clinical LADA.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Coloured Rice Phenolic Extracts Increase Expression of Genes Associated with Insulin Secretion in Rat Pancreatic Insulinoma β-cells.International journal of molecular sciences · 2020Article
- Genotypes of HLA, TCF7L2, and FTO as potential modifiers of the association between sweetened beverage consumption and risk of LADA and type 2 diabetes.European journal of nutrition · 2020Article
- Glucose fluctuation increased mesangial cell apoptosis related to AKT signal pathway.Archives of medical science : AMS · 2019Article
- GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein.Frontiers in pharmacology · 2019Article
- Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling.Molecular medicine (Cambridge, Mass.) · 2018Article
- Oxidative Stress in Pancreatic Beta Cell Regeneration.Oxidative medicine and cellular longevity · 2017Review
- LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells.Endocrine · 2016Article
- Blood glucose fluctuation accelerates renal injury involved to inhibit the AKT signaling pathway in diabetic rats.Endocrine · 2016Article
- Sugar intake is associated with progression from islet autoimmunity to type 1 diabetes: the Diabetes Autoimmunity Study in the Young.Diabetologia · 2015Article
- Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?Diabetes & metabolism journal · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesGlucose fluctuations are both strong predictor of diabetic complications and crucial factor for beta cell damages. Here we investigated the effect of intermittent high glucose (IHG) on both cell apoptosis and proliferation activity in INS-1 cells and the potential mechanisms.
methodsCells were treated with normal glucose (5.5 mmol/L), constant high glucose (CHG) (25 mmol/L), and IHG (rotation per 24 h in 11.1 or 25 mmol/L) for 7 days. Reactive oxygen species (ROS), xanthine oxidase (XOD) level, apoptosis, cell viability, cell cycle, and expression of cyclinD1, p21, p27, and Skp2 were determined.
resultsWe found that IHG induced more significant apoptosis than CHG and normal glucose; intracellular ROS and XOD levels were more markedly increased in cells exposed to IHG. Cells treated with IHG showed significant decreased cell viability and increased cell proportion in G0/G1 phase. Cell cycle related proteins such as cyclinD1 and Skp2 were decreased significantly, but expressions of p27 and p21 were increased markedly.
conclusionsThis study suggested that IHG plays a more toxic effect including both apoptosis-inducing and antiproliferative effects on INS-1 cells. Excessive activation of cellular stress and regulation of cyclins might be potential mechanism of impairment in INS-1 cells induced by IHG.
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