Trial reportBioMed research international2014
Hypothalamus-anchored resting brain network changes before and after sertraline treatment in major depression.
Trial report in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- A systematic review of relations between resting-state functional-MRI and treatment response in major depressive disorder.Journal of affective disorders · 2015Pooled it
- Sertraline plus deanxit to treat patients with depression and anxiety in chronic somatic diseases: a randomized controlled trial.BMC psychiatry · 2015Trial
- Dynamics of cerebral blood flow following sertraline treatment in adolescent depression.Frontiers in psychiatry · 2025Article
- Functional cerebello-cortico-limbic connectivity in aggression: A resting-state 7T fMRI study in healthy volunteers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo).Frontiers in neuroscience · 2024Article
- Changes in functional connectivity among vestibulo-visuo-somatosensory and spatial cognitive cortical areas in persistent postural-perceptual dizziness: resting-state fMRI studies before and after visual stimulation.Frontiers in neurology · 2023Article
- Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response.BMC psychiatry · 2022Article
- Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder.Translational psychiatry · 2021Article
- Spontaneous thought-related network connectivity predicts sertraline effect on major depressive disorder.Brain imaging and behavior · 2021Article
- A Treatment-Response Comparison Study of Resting-State Functional Magnetic Resonance Imaging Between Standard Treatment of SSRI and Standard Treatment of SSRI Plus Non-dominant Hand-Writing Task in Patients With Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Brain Networks Reveal the Effects of Antipsychotic Drugs on Schizophrenia Patients and Controls.Frontiers in psychiatry · 2019Article
- Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats.Experimental & molecular medicine · 2018Article
- Limbic Intrinsic Connectivity in Depressed and High-Risk Youth.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study.Frontiers in psychiatry · 2018Article
- Emotion Regulating Attentional Control Abnormalities In Major Depressive Disorder: An Event-Related Potential Study.Scientific reports · 2017Article
- Consensus Paper: Cerebellum and Emotion.Cerebellum (London, England) · 2017Article
- Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE.NeuroImage. Clinical · 2017Article
- Neural Correlates of Antidepressant Treatment Response in Adolescents with Major Depressive Disorder.Journal of child and adolescent psychopharmacology · 2016Article
- Resting-state connectivity predictors of response to psychotherapy in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Changes in brain connectivity related to the treatment of depression measured through fMRI: a systematic review.Frontiers in human neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sertraline, one of the oldest antidepressants, remains to be the most efficacious treatment for depression. However, major depression disorder (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive hypothalamus activity. The purpose of this study was to examine the effects of antidepressant treatment (sertraline) on hypothalamus-anchored resting brain circuitry. Functional magnetic resonance imaging was conducted on depressed patients (n = 12) both before and after antidepressant treatment. After eight weeks of antidepressant treatment, patients with depression showed significantly increased connectivity between the hypothalamus and dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, insula, putamen, caudate, and claustrum. By contrast, decreased connectivity of the hypothalamus-related areas was primarily located in the inferior frontal gyrus, medial frontal gyrus, cingulated gyrus, precuneus, thalamus, and cerebellum. After eight weeks of antidepressant therapy, 8 out of the 12 depressed subjects achieved 70% reduction or better in depressive symptoms, as measured on the Hamilton depression rating scale. Our findings may infer that antidepressant treatment can alter the functional connectivity of the hypothalamus resting brain to achieve its therapeutic effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.