Evidence map›Paper›PMID 24772418›Full record

ReviewBioMed research international2014

Biomarkers for sepsis: a review with special attention to India.

George E Nelson, Vidya Mave, Amita Gupta

Abstract readReview
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Considering the Effect ofTurkish journal of pharmaceutical sciences · 2019
    Article
  6. The Pathogenesis of Sepsis and Potential Therapeutic Targets.International journal of molecular sciences · 2019
    Review
  7. Article
  8. Article
  9. Article
  10. Could Neutrophil CD64 Expression Be Used as a Diagnostic Parameter of Bacteremia in Patients with Febrile Neutropenia?Turkish journal of haematology : official journal of Turkish Society of Haematology · 2017
    Article
  11. The role of C-reactive protein as a diagnostic predictor of sepsis in a multidisciplinary Intensive Care Unit of a tertiary care center in Nepal.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2016
    Article
  12. Procalcitonin levels in salmonella infection.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015
    Article
  13. Article
  14. Sepsis induced by Staphylococcus aureus: participation of biomarkers in a murine model.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George E NelsonDivision of Infectious Diseases, The Johns Hopkins University School of Medicine, 1830 East Monument Street Suite 450B, Baltimore, MD 21287, USA.
Vidya MaveDivision of Infectious Diseases, The Johns Hopkins University School of Medicine, 1830 East Monument Street Suite 450B, Baltimore, MD 21287, USA ; BJMC Clinical Trials Unit, BJ Medical College and Sassoon General Hospitals, Jai Prakash Narayan Road, Pune 411 001, India.ORCID 0000-0001-8509-4517
Amita GuptaDivision of Infectious Diseases, The Johns Hopkins University School of Medicine, 1830 East Monument Street Suite 450B, Baltimore, MD 21287, USA ; Center for Clinical Global Health Education, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Funding

RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
NIAID NIH HHS T32 AI007291
6 · The paper itself

Abstract

Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections. Biomarkers have been used in a variety of disease processes and can help aid in diagnosing bacterial infections. There have been numerous biomarkers investigated to aid with diagnosis and prognostication in sepsis with the majority suffering from lack of sensitivity or specificity. Procalcitonin has been heralded as the biomarker that holds the most promise for bloodstream infections. Data are emerging in India, and in this review, we focus on the current data of biomarkers in sepsis with particular attention to how biomarkers could be used to augment diagnosis and treatment in India.

Indexed as

BiomarkersCalcitoninCalcitonin Gene-Related PeptideHumansIndiaMembrane GlycoproteinsProtein PrecursorsReceptors, ImmunologicSepsisTriggering Receptor Expressed on Myeloid Cells-1BiomarkersCALCA protein, humanCalcitoninCalcitonin Gene-Related PeptideMembrane GlycoproteinsProtein PrecursorsReceptors, ImmunologicTREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1

Identifiers

PMID24772418
PMCPMC3977532

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.