Evidence map›Paper›PMID 24772414›Full record

ReviewBioMed research international2014

Protein nanoparticles as drug delivery carriers for cancer therapy.

Warangkana Lohcharoenkal, Liying Wang, Yi Charlie Chen, Yon Rojanasakul

Abstract readReview
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed.

  1. Review
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  8. Development,Drug delivery · 2025
    Article
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Warangkana LohcharoenkalDepartment of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA.
Liying WangPathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Yi Charlie ChenNatural Science Division, Alderson-Broaddus College, Philippi, WV 26416, USA.
Yon RojanasakulDepartment of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA ; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.ORCID 0000-0002-8839-6462

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Prediction and Mechanism of Carbon Nanotube-Induced FibrosisR01HL095579 · NHLBI · WEST VIRGINIA UNIVERSITY · PI ROJANASAKUL, YON · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL095579NHLBI NIH HHS R01-HL095579NIGMS NIH HHS P20 GM103434
6 · The paper itself

Abstract

Nanoparticles have increasingly been used for a variety of applications, most notably for the delivery of therapeutic and diagnostic agents. A large number of nanoparticle drug delivery systems have been developed for cancer treatment and various materials have been explored as drug delivery agents to improve the therapeutic efficacy and safety of anticancer drugs. Natural biomolecules such as proteins are an attractive alternative to synthetic polymers which are commonly used in drug formulations because of their safety. In general, protein nanoparticles offer a number of advantages including biocompatibility and biodegradability. They can be prepared under mild conditions without the use of toxic chemicals or organic solvents. Moreover, due to their defined primary structure, protein-based nanoparticles offer various possibilities for surface modifications including covalent attachment of drugs and targeting ligands. In this paper, we review the most significant advancements in protein nanoparticle technology and their use in drug delivery arena. We then examine the various sources of protein materials that have been used successfully for the construction of protein nanoparticles as well as their methods of preparation. Finally, we discuss the applications of protein nanoparticles in cancer therapy.

Indexed as

Antineoplastic AgentsDrug CarriersDrug Delivery SystemsHumansNanoparticlesNeoplasmsPolymersProteinsAntineoplastic AgentsDrug CarriersPolymersProteins

Identifiers

PMID24772414
PMCPMC3977416

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.