ArticlePreventive nutrition and food science2014
Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats.
Article in Preventive nutrition and food science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 104 citations in OpenAlex.
- Manganese: biology, physiology and role in disease.Cell discovery · 2026Review
- Enhancing salinity tolerance and growth of Spinacia oleracea L. using halophilic plant growth-promoting bacteria.Scientific reports · 2026Article
- Nutrient and Phytochemical Composition of Nine African Leafy Vegetables: A Comparative Study.Foods (Basel, Switzerland) · 2025Article
- The Effect of one-week spinach and NBS superfood supplementation on interleukin-6, superoxide dismutase, and malondialdehyde levels after repeated bouts of wingate test in trained men.Nutrition & metabolism · 2025Article
- Chemical Characterization and Comparative Biological Activities ofBiochemistry research international · 2025Article
- SolarplastInternational journal of molecular sciences · 2024Article
- Herbo-vitamin medicine Livogrit Vital ameliorates isoniazid induced liver injury (IILI) in human liver (HepG2) cells by decreasing isoniazid accumulation and oxidative stress driven hepatotoxicity.BMC complementary medicine and therapies · 2024Article
- Ecdysterone and Turkesterone-Compounds with Prominent Potential in Sport and Healthy Nutrition.Nutrients · 2024Review
- Review
- Hepatoprotective Mechanisms Induced by Spinach Methanolic Extract in Rats with Hyperglycemia-An Immunohistochemical Analysis.Antioxidants (Basel, Switzerland) · 2023Article
- SolarplastPlants (Basel, Switzerland) · 2023Article
- Health-Promoting Nutrients and Potential Bioaccessibility of Breads Enriched with Fresh Kale and Spinach.Foods (Basel, Switzerland) · 2022Article
- Article
- Laboratory scale medicinal plants mediated green synthesis of biocompatible nanomaterials and their versatile biomedical applications.Saudi journal of biological sciences · 2022Review
- Administration of hydro-alcoholic extract of spinach improves oxidative stress and inflammation in high-fat diet-induced NAFLD rats.BMC complementary medicine and therapies · 2021Article
- Antioxidant Properties of Fruit and Vegetable Whey Beverages and Fruit and Vegetable Mousses.Molecules (Basel, Switzerland) · 2021Article
- Spinach Methanolic Extract Attenuates the Retinal Degeneration in Diabetic Rats.Antioxidants (Basel, Switzerland) · 2021Article
- Spinach consumption and nonalcoholic fatty liver disease among adults: a case-control study.BMC gastroenterology · 2021Article
- Biological Effect of Different Spinach Extracts in Comparison with the Individual Components of the Phytocomplex.Foods (Basel, Switzerland) · 2021Article
- Vegetable Soups and Creams: Raw Materials, Processing, Health Benefits, and Innovation Trends.Plants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased consumption of fresh vegetables that are high in polyphenols has been associated with a reduced risk of oxidative stress-induced disease. The present study aimed to evaluate the antioxidant effects of spinach in vitro and in vivo in hyperlipidemic rats. For measurement of in vitro antioxidant activity, spinach was subjected to hot water extraction (WE) or ethanol extraction (EE) and examined for total polyphenol content (TPC), oxygen radical absorbance capacity (ORAC), cellular antioxidant activity (CAA), and antigenotoxic activity. The in vivo antioxidant activity of spinach was assessed using blood and liver lipid profiles and antioxidant status in rats fed a high fat-cholesterol diet (HFCD) for 6 weeks. The TPC of WE and EE were shown as 1.5±0.0 and 0.5±0.0 mg GAE/g, respectively. Increasing the concentration of the extracts resulted in increased ORAC value, CAA, and antigenotoxic activity for all extracts tested. HFCD-fed rats displayed hyperlipidemia and increased oxidative stress, as indicated by a significant rise in blood and liver lipid profiles, an increase in plasma conjugated diene concentration, an increase in liver thiobarbituric acid reactive substances (TBARS) level, and a significant decrease in manganese superoxide dismutase (Mn-SOD) activity compared with rats fed normal diet. However, administration of 5% spinach showed a beneficial effect in HFCD rats, as indicated by decreased liver TBARS level and DNA damage in leukocyte and increased plasma conjugated dienes and Mn-SOD activity. Thus, the antioxidant activity of spinach may be an effective way to ameliorate high fat and cholesterol diet-induced oxidative stress.
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