ArticleJournal of gastrointestinal oncology2014
Sentinel lymph node in oesophageal cancer-a systematic review and meta-analysis.
Article in Journal of gastrointestinal oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Sentinel Node Navigation Surgery for Upper Gastrointestinal Malignancies: Current Status, Clinical Significance, and Future Perspectives.Magyar onkologia · 2026Review
- Lymphatic Metastasis of Esophageal Squamous Cell Carcinoma: The Role of NRF2 and Therapeutic Strategies.Cancers · 2025Review
- [Evidence for the extent and oncological benefit of lymphadenectomy for esophageal cancer].Chirurgie (Heidelberg, Germany) · 2025Article
- Semaphorin 3F (SEMA3F) influences patient survival in esophageal adenocarcinoma.Scientific reports · 2024Article
- Extensive lymphadenectomy may improve survival in node negative oesophageal cancer.Scientific reports · 2024Article
- The different routes of lymph node metastases in esophageal cancer and its significance.Journal of thoracic disease · 2023Article
- Feasibility of sentinel node navigated surgery in high-risk T1b esophageal adenocarcinoma patients using a hybrid tracer of technetium-99 m and indocyanine green.Surgical endoscopy · 2022Article
- Near-Infrared Fluorescent Image-Guided Lymphatic Mapping in Esophageal Squamous Cell Carcinoma.Annals of surgical oncology · 2020Article
- Sentinel node navigation surgery in esophageal cancer.Annals of gastroenterological surgery · 2019Review
- Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging.Journal of laparoendoscopic & advanced surgical techniques. Part A · 2017Article
- Lymphadenectomy and health-related quality of life after oesophageal cancer surgery: a nationwide, population-based cohort study.BMJ open · 2016Article
- Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSentinel lymph nodes (SLNs) have been used to predict regional lymph node metastasis in patients with melanoma and breast cancer. However, the validity of the SLN hypothesis is still controversial for oesophageal cancer. We performed this meta-analysis to evaluate the feasibility and accuracy of radio-guided SLN mapping for oesophageal cancer.
methodsA systematic search was conducted using MEDLINE, PubMed, EMBASE, Current Contents Connect, Cochrane library, Google scholar, Science Direct, and Web of Science. Original data was abstracted from each study and used to calculate a pooled event rates and 95% confidence interval (95% CI).
resultsThe search identified 23 relevant articles. The overall detection rate was 0.93 (95% CI: 0.894-0.950), sensitivity 0.87 (95% CI: 0.811-0.908), negative predictive value 0.77 (95% CI: 0.568-0.890) and the accuracy was 0.88 (95% CI: 0.817-0.921). In the adenocarcinoma cohort, detection rate was 0.98 (95% CI: 0.923-0.992), sensitivity 0.84 (95% CI: 0.743-0.911) and the accuracy was 0.87(95% CI: 0.796-0.913). In the squamous cell carcinoma group, detection rate was 0.89 (95% CI: 00.792-0.943), sensitivity 0.91 (95% CI: 0.754-0.972) and the accuracy was 0.84 (95% CI: 0.732-0.914).
conclusionsIt is possible to identify and obtain a SLN before neoadjuvant therapy in oesophageal cancer. However, further work is needed to optimize radiocolloid type, refine the technique and develop a quick and accurate way to determine SLN status intraoperatively. This technique has to be further evaluated before it can be applied widely.
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