ArticleCancer prevention research (Philadelphia, Pa.)2014
Evaluation of clinical criteria for the identification of Lynch syndrome among unselected patients with endometrial cancer.
Article in Cancer prevention research (Philadelphia, Pa.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of universal screening in major lynch-associated tumors: a systematic review of literature.Familial cancer · 2022Pooled it
- The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Pooled it
- Context-dependent environmental associations with endometrial cancer histotype and genotype.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Article
- Updates in gynecologic care for individuals with lynch syndrome.Frontiers in oncology · 2023Review
- Article
- Mismatch Repair Universal Screening of Endometrial Cancers (MUSE) in a Canadian Cohort.Current oncology (Toronto, Ont.) · 2021Article
- Endometrial Tumors with MSI-H and dMMR Share a Similar Tumor Immune Microenvironment.OncoTargets and therapy · 2021Article
- Cost-Effectiveness of the Manchester Approach to Identifying Lynch Syndrome in Women with Endometrial Cancer.Journal of clinical medicine · 2020Article
- Prevalence and Molecular Characterization of Defective DNA Mismatch Repair in Small-bowel Carcinoma in a Japanese Hospital-based Population.Journal of the anus, rectum and colon · 2020Article
- Germline mismatch repair gene variants analyzed by universal sequencing in Japanese cancer patients.Cancer medicine · 2019Article
- Endometrioid endometrial cancer "recurring" as high-grade serous adenocarcinoma in the inguinal lymph nodes in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence?Hereditary cancer in clinical practice · 2019Article
- Cancer susceptibility gene mutations in type I and II endometrial cancer.Gynecologic oncology · 2019Article
- Understanding inherited risk in unselected newly diagnosed patients with endometrial cancer.JCO precision oncology · 2019Article
- Article
- Screening for Lynch syndrome using risk assessment criteria in patients with ovarian cancer.Journal of gynecologic oncology · 2018Article
- Importance of PCR-based Tumor Testing in the Evaluation of Lynch Syndrome-associated Endometrial Cancer.Advances in anatomic pathology · 2017Review
- Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer.Japanese journal of clinical oncology · 2017Article
- Clinical Challenges Associated with Universal Screening for Lynch Syndrome-Associated Endometrial Cancer.Cancer prevention research (Philadelphia, Pa.) · 2017Article
- Germline multi-gene hereditary cancer panel testing in an unselected endometrial cancer cohort.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Laboratory Assays in Evaluation of Lynch Syndrome in Patients with Endometrial Carcinoma.Surgical pathology clinics · 2016Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Clinical criteria, primarily young age of cancer onset and family history of signature cancers, have been developed to identify individuals at elevated risk for Lynch syndrome with the goals of early identification and cancer prevention. In 2007, the Society of Gynecologic Oncology (SGO)-codified criteria for women presenting with gynecologic cancers. These criteria have not been validated in a population-based setting. For 412 unselected endometrial cancers, immunohistochemical expression of DNA mismatch repair proteins and MLH1 methylation were assessed to classify tumors as sporadic or probable Lynch syndrome (PLS). In this cohort, 10.5% of patients were designated as PLS based on tumor testing. The sensitivity and specificity of the SGO criteria to identify these same cases were 32.6% [95% confidence interval (CI), 19.2-48.5] and 77% (95% CI, 72.7-81.8), respectively. With the exception of tumor location in the lower uterine segment, multivariate analysis of clinical features, family history, and pathologic variables failed to identify significant differences between the sporadic and PLS groups. A simplified cost-effectiveness analysis demonstrated that the SGO clinical criteria and universal tissue testing strategies had comparable costs per patient with PLS identified. In conclusion, the SGO criteria successfully identify PLS cases among women with endometrial cancer who are young or have significant family history of signature tumors. However, a larger proportion of patients with PLS who are older and have less significant family history are not detected by this screening strategy. Universal tissue testing may be necessary to capture more individuals at risk for having Lynch syndrome.
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