ArticleInternational journal of cancer2014
Body mass index at early adulthood, subsequent weight change and cancer incidence and mortality.
Article in International journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03254940 (Charge), which is not on this map. Cited by 44 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Charge: Optimizing a Standalone Text Messaging-Based Weight Loss Intervention
Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Early-life anthropometry and colorectal cancer risk in adulthood: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis of prospective studies.International journal of cancer · 2025Pooled it
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk.GeroScience · 2025Pooled it
- Pooled it
- Is the association of overweight and obesity with colorectal cancer underestimated? An umbrella review of systematic reviews and meta-analyses.European journal of epidemiology · 2023Pooled it
- Early-life body mass index and risks of breast, endometrial, and ovarian cancers: a dose-response meta-analysis of prospective studies.British journal of cancer · 2022Pooled it
- Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- The impact of patient characteristics and lifestyle factors on the risk of an ipsilateral event after a primary DCIS: A systematic review.Breast (Edinburgh, Scotland) · 2020Pooled it
- Obesity at age 20 and weight gain during adulthood increase risk of total and premature all-cause mortality: findings from women attending breast screening in Manchester.BMC women's health · 2023Trial
- Height and bone mineral density are associated with naevus count supporting the importance of growth in melanoma susceptibility.PloS one · 2015Trial
- Obesity and colorectal cancer risk: A systematic review and meta-analysis.World journal of clinical oncology · 2026Article
- Article
- Body size and occupational physical activity during the life course and gastrointestinal cancers.American journal of epidemiology · 2025Article
- Variation by age, smoking, and menopausal status in the impact of body mass index change on liver cancer risk.Scientific reports · 2025Article
- Age and sex differences in the relationship of body weight changes with colon cancer risks: A nationwide cohort study.Scientific reports · 2025Article
- Associations of life course obesity with endometrial cancer: could alternative categorization of BMI change improve inference about cumulative risks?International journal of epidemiology · 2024Article
- Exploring the optimal indicator of short-term peridiagnosis weight dynamics to predict cancer survival: A multicentre cohort study.Journal of cachexia, sarcopenia and muscle · 2024Article
- Gender differences in midlife to later-life cumulative burden and variability of obesity measures and risk of all-cause and cause-specific mortality.International journal of obesity (2005) · 2024Article
- Body size over the adult life course and the risk of colorectal cancer among postmenopausal women.Public health nutrition · 2023Observational
- The timing of adiposity and changes in the life course on the risk of cancer.Cancer metastasis reviews · 2022Review
- Obesity and Breast Cancer Risk: The Oncogenic Implications of Metabolic Dysregulation.The Journal of clinical endocrinology and metabolism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Obesity later in adulthood is associated with increased risks of many cancers. However, the effect of body fatness in early adulthood, and change in weight from early to later adulthood on cancer risk later in life is less clear. We used data from 13,901 people aged 45-64 in the Atherosclerosis Risk in Communities cohort who at baseline (1987-1989) self-reported their weight at the age of 25 and had weight and height measured. Incident cancers were identified through 2006 and cancer deaths were ascertained through 2009. Multivariable Cox proportional hazard models were used to relate body mass index (BMI) at age 25 and percent weight change from age 25 to baseline to cancer incidence and mortality. After adjusting for weight change from age 25 until baseline, a 5 kg/m(2) increment in BMI at age 25 was associated with a greater risk of incidence of all cancers in women [hazard ratio (95% confidence interval): 1.10 (1.02-1.20)], but not in men. Associations with incident endometrial cancer were strong [1.83 (1.47-2.26)]. After adjusting for BMI at age 25, a 5% increment in weight from age 25 to baseline was associated with a greater risk of incident postmenopausal breast cancer [1.05 (1.02-1.07)] and endometrial cancer [1.09 (1.04-1.14)] in women and incident colorectal cancer [1.05 (1.00-1.10)] in men. Excess weight during young adulthood and weight gain from young to older adulthood may be independently associated with subsequent cancer risk. Excess weight and weight gain in early adulthood should be avoided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.