Evidence map›Paper›PMID 24771332›Full record

ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014

Emerging technologies for rapid identification of bloodstream pathogens.

Atul Kothari, Margie Morgan, David A Haake

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 146 citations in OpenAlex.

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  17. Rapid identification of sepsis in the emergency department.Journal of the American College of Emergency Physicians open · 2023
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Atul KothariDivision of Infectious Diseases, VA Greater Los Angeles Healthcare System.
Margie MorganDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center.
David A HaakeDivision of Infectious Diseases, VA Greater Los Angeles Healthcare System Departments of Medicine, Urology, and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California.
Cedars-Sinai Medical Center · USUniversity of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

Rapid identification and antibiotic susceptibility testing of sepsis pathogensR21AI109889 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAAKE, DAVID A · 2014 to 2015
$409k
NIAID NIH HHS R21 AI109889
6 · The paper itself

Abstract

Technologies for rapid microbial identification are poised to revolutionize clinical microbiology and enable informed decision making for patients with life-threatening bloodstream infections. Species identification of microorganisms in positive blood cultures can be performed in minutes using commercial fluorescence in situ hybridization tests or mass spectroscopy. Microorganisms in positive blood cultures can also be identified within 1-2.5 hours using automated polymerase chain reaction-based systems that can also detect selected antibiotic resistance markers, such as methicillin resistance. When combined with antibiotic stewardship programs, these approaches improve clinical outcomes and reduce healthcare expenditures. Tests for direct detection in whole blood samples are highly desirable because of their potential to identify bloodstream pathogens without waiting 1-2 days for blood cultures to become positive. However, results for pathogen detection in whole blood do not overlap with those of conventional blood culture techniques and we are still learning how best to use these approaches.

Indexed as

Anti-Bacterial AgentsAutomation, LaboratoryBloodDrug UtilizationHealth PolicyHumansMicrobiological TechniquesMolecular Diagnostic TechniquesSepsisTime FactorsAnti-Bacterial Agentsantimicrobial stewardshipbloodstream infectionsclinical microbiologymolecular diagnosticsrapid diagnostics

Identifiers

PMID24771332
PMCPMC4368854
OpenAlexW2114194563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.