Evidence map›Paper›PMID 24771276›Full record

ArticleInternational journal of epidemiology2015

Cohort Profile: Recruitment cohorts in the neuropsychological substudy of the Multicenter AIDS Cohort Study.

James T Becker, Lawrence A Kingsley, Samantha Molsberry, Sandra Reynolds, Aaron Aronow, Andrew J Levine, Eileen Martin, Eric N Miller, Cynthia A Munro, Ann Ragin and 2 more

Abstract readMulticenter Study
In one paragraph

Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

James T BeckerDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA, Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA, Department of Psychology, Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA, beckerjt@upmc.edu.
Lawrence A KingsleyDepartment of Psychology, Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Samantha MolsberryDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Sandra ReynoldsDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Aaron AronowDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Andrew J LevineDepartment of Neurology, University of California, Los Angeles, CA, USA, .
Eileen MartinDepartment of Psychiatry, Rush University School of Medicine, Chicago, IL, USA.
Eric N MillerDepartment of Psychiatry, University of California, Los Angeles, CA, USA.
Cynthia A MunroDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA and.
Ann RaginDepartment of Radiology, Northwestern University, Evanston, IL, USA.
Ned SacktorDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA and.
Ola A SelnesDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA and.

Funding

NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
METHODOLOGICAL EXPERTISE IN INTREPRETING MACS DATAU01AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACOBSON, LISA P · 1993 to 2011
$26.9M
YALE CENTER FOR THE: LEARNING &ATTENTIONP41RR013642 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARER, ELAINE L · 1998 to 2011
$21.9M
Center for the Analysis & Management of the Multicenter AIDS Cohort StudyUM1AI035043 · NIAID · JOHNS HOPKINS UNIVERSITY · PI D'SOUZA, GYPSYAMBER, JACOBSON, LISA P · 2012 to 2018
$20.7M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U01DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MUNOZ, ALVARO · 2003 to 2017
$17.9M
Cardiovascular and HIV/AIDS Effects on Brain Structure/Function and CognitionR01AG034852 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 2010 to 2020
$9.2M
Magnetoencephalography as a Biomarker for HIV-Associated Neurocognitive DisorderR21MH098745 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 2012 to 2013
$398k
NCATS NIH HHS UL1-TR000424NCRR NIH HHS P41 RR013642NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI035043NIAID NIH HHS U01-AI35039NIAID NIH HHS U01-AI35040NIAID NIH HHS U01-AI35041NIAID NIH HHS U01-AI35042NIAID NIH HHS UM1 AI035043NIAID NIH HHS UM1-AI35043NIA NIH HHS AG034852NIA NIH HHS R01 AG034852NIDDK NIH HHS U01 DK066116NIMH NIH HHS MH098745NIMH NIH HHS R21 MH098745
6 · The paper itself

Abstract

The Multicenter AIDS Cohort Study (MACS) is one of the largest and longest running studies of the natural and treated history of HIV disease. The Neuropsychological (NP) substudy was begun in 1988 following reports of significant adverse neurological consequences of HIV disease, including dementia. The goal was to characterize the neuropsychological deficits among individuals with HIV disease, and track the natural history of the neurological complications over time. There were three distinct MACS recruitment stages that focused on different groups of HIV-infected men, or men at risk for infection. Initially, a subcohort was evaluated semi-annually with NP tests but, beginning in 2005, the entire group of MACS participants have had NP examinations biannually, unless closer follow-up was warranted. The participants complete a battery of NP tests, and are classified as either normal, mildly or severely impaired using the Antinori criteria for HIV-Associated Neurocognitive Disorder (HAND). Additional behavioural data, including mood state and psychoactive substance use, are recorded as part of the main MACS data collection. The MACS public data set (PDS) has been available since 1994 and includes baseline and 6-monthly follow-up data. Beginning in October 1995, the PDS has been released annually with new releases superseding previous versions.

Indexed as

Patient SelectionAcquired Immunodeficiency SyndromeAdultAntiretroviral Therapy, Highly ActiveCognition DisordersCohort StudiesDementiaHomosexuality, MaleHumansMaleMiddle AgedNeuropsychological Tests

Identifiers

PMID24771276
PMCPMC4681102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.