ArticleBrain structure & function2015
Abnormalities in structural covariance of cortical gyrification in schizophrenia.
Article in Brain structure & function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Structural covariance networks in schizophrenia: A systematic review Part II.Schizophrenia research · 2022Pooled it
- Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis: The OPTiMiSE Study.Schizophrenia bulletin · 2021Trial
- Effects of Long-term Diving Training on Cortical Gyrification.Scientific reports · 2016Trial
- Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.Molecular psychiatry · 2026Article
- Aberrant network topology of cortical-subcortical circuits in schizophrenia and bipolar disorder: a graph theory study.Frontiers in psychiatry · 2026Article
- Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis.CNS neuroscience & therapeutics · 2025Article
- [Illness duration-related developmental trajectory of progressive cerebral gray matter changes in schizophrenia].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Exploring the predictive value of structural covariance networks for the diagnosis of schizophrenia.Frontiers in psychiatry · 2025Article
- Machine learning in small sample neuroimaging studies: Novel measures for schizophrenia analysis.Human brain mapping · 2024Article
- Brain Network Topology in Deficit and Non-Deficit Schizophrenia: Application of Graph Theory to Local and Global Indices.Journal of personalized medicine · 2023Article
- In vivo characterization of magnetic resonance imaging-based T1w/T2w ratios reveals myelin-related changes in temporal lobe epilepsy.Human brain mapping · 2023Article
- Morphometric dis-similarity between cortical and subcortical areas underlies cognitive function and psychiatric symptomatology: a preadolescence study from ABCD.Molecular psychiatry · 2023Article
- Neurological soft signs and structural network changes: a longitudinal analysis in first-episode schizophrenia.BMC psychiatry · 2023Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Decreased integration of default-mode network during a working memory task in schizophrenia with severe attention deficits.Frontiers in cellular neuroscience · 2022Article
- Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis.Molecular psychiatry · 2021Article
- Structural Covariance of Cortical Gyrification at Illness Onset in Treatment Resistance: A Longitudinal Study of First-Episode Psychoses.Schizophrenia bulletin · 2021Article
- Age-related decrements in cortical gyrification: Evidence from an accelerated longitudinal dataset.The European journal of neuroscience · 2021Article
- Developmental pattern of the cortical topology in high-functioning individuals with autism spectrum disorder.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The highly convoluted shape of the adult human brain results from several well-coordinated maturational events that start from embryonic development and extend through the adult life span. Disturbances in these maturational events can result in various neurological and psychiatric disorders, resulting in abnormal patterns of morphological relationship among cortical structures (structural covariance). Structural covariance can be studied using graph theory-based approaches that evaluate topological properties of brain networks. Covariance-based graph metrics allow cross-sectional study of coordinated maturational relationship among brain regions. Disrupted gyrification of focal brain regions is a consistent feature of schizophrenia. However, it is unclear if these localized disturbances result from a failure of coordinated development of brain regions in schizophrenia. We studied the structural covariance of gyrification in a sample of 41 patients with schizophrenia and 40 healthy controls by constructing gyrification-based networks using a 3-dimensional index. We found that several key regions including anterior insula and dorsolateral prefrontal cortex show increased segregation in schizophrenia, alongside reduced segregation in somato-sensory and occipital regions. Patients also showed a lack of prominence of the distributed covariance (hubness) of cingulate cortex. The abnormal segregated folding pattern in the right peri-sylvian regions (insula and fronto-temporal cortex) was associated with greater severity of illness. The study of structural covariance in cortical folding supports the presence of subtle deviation in the coordinated development of cortical convolutions in schizophrenia. The heterogeneity in the severity of schizophrenia could be explained in part by aberrant trajectories of neurodevelopment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.