ArticleThe international journal of cardiovascular imaging2014
Gender- and age-related differences in rest and post-stress left ventricular cardiac function determined by gated SPECT.
Article in The international journal of cardiovascular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Heart failure with supranormal ejection fraction: clinical characteristics and outcomes compared to mildly reduced and preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Left ventricular ejection fraction, myocardial blood flow and hemodynamic variables in adenosine and regadenoson vasodilator 82-Rubidium PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Microvascular dysfunction and sympathetic hyperactivity in women with supra-normal left ventricular ejection fraction (snLVEF).European journal of nuclear medicine and molecular imaging · 2020Article
- Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry.European heart journal. Cardiovascular Imaging · 2020Article
- Successful innovation: A time for change?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Adopting new gamma cameras and reconstruction algorithms: Do we need to re-establish normal reference values?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Cardiovascular imaging 2014 in the International Journal of Cardiovascular Imaging.The international journal of cardiovascular imaging · 2015Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gender- and age-related changes of left ventricular (LV) function and dimensions have not been elucidated in a large population by gated SPECT. Thus, the aim of this study was to derive male and female reference limits for left ventricular functional parameters, and determine the effect of age on LV dimensions and systolic function for this imaging modality. 1,639 (53% males) subjects without cardiovascular disease who underwent cardiac SPECT between January 2002 and June 2012 were included in this study. Mean age at presentation was 61 ± 12 years (range 18-92 years). A significant effect of age (p = 0.011) and gender (p < 0.0001) on resting LV ejection fraction (LVEF) was observed, with an increase in LVEF with age being more pronounced in women (ΔB-coefficient: -0.088, p = 0.011). Overall, mean LVEF was higher in women compared to men (70.3 ± 8.6% vs. 64.4 ± 7.5%, p < 0.0001). LVEF after pharmacological stress with adenosine was significantly lower than at rest in both women and men (∆LVEF = 1.1% in males and ∆LVEF = 1.6% in females, p = 0.01), which was the result of a significant increase in end-systolic volume after stress (p = 0.0001). With advancing age an increase in LVEF was observed that was more pronounced in women than in men. These findings indicate that the evaluation of cardiac function and volumes of patients by gated SPECT should consider age- and gender-matched normative values.
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