ArticleApplied and environmental microbiology2014
Protective effects of Lactobacillus plantarum CCFM8610 against chronic cadmium toxicity in mice indicate routes of protection besides intestinal sequestration.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 127 citations in OpenAlex.
- Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study.European journal of nutrition · 2020Trial
- Mitigating Cadmium Toxicity: The Therapeutic Potential of Lactobacillus acidophilus Pro4 in Mice.Probiotics and antimicrobial proteins · 2026Article
- Functional characterization of CreA, ZnT, and MTase as key regulators of cadmium resistance inFrontiers in microbiology · 2026Article
- Effects of Distiller's Grains Biochar andMicroorganisms · 2024Article
- Adsorption of CdMicroorganisms · 2024Article
- The Involvement of Lactic Acid Bacteria and Their Exopolysaccharides in the Biosorption and Detoxication of Heavy Metals in the Gut.Biological trace element research · 2024Review
- Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions.Environmental pollution (Barking, Essex : 1987) · 2023Review
- Screening and Identification of Probiotic Lactobacilli from the Infant Gut Microbiota to Alleviate Lead Toxicity.Probiotics and antimicrobial proteins · 2023Article
- Orally AdministratedInternational journal of molecular sciences · 2023Article
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- Threonine Facilitates Cd Excretion by Increasing the Abundance of GutMolecules (Basel, Switzerland) · 2022Article
- Biological Effects of Human Exposure to Environmental Cadmium.Biomolecules · 2022Review
- Oleic Acid Facilitates Cd Excretion by Increasing the Abundance ofInternational journal of molecular sciences · 2022Article
- The Complex Role of Lactic Acid Bacteria in Food Detoxification.Nutrients · 2022Review
- Engineered Bacteria EcN-MT Alleviate Liver Injury in Cadmium-Exposed MiceFrontiers in pharmacology · 2022Article
- Parkinson's Disease and the Metal-Microbiome-Gut-Brain Axis: A Systems Toxicology Approach.Antioxidants (Basel, Switzerland) · 2021Review
- Protective Effects ofInternational journal of molecular sciences · 2021Article
- Assessment of Pb(II), Cd(II), and Al(III) Removal Capacity of Bacteria from Food and Gut Ecological Niches: Insights into Biodiversity to Limit Intestinal Biodisponibility of Toxic Metals.Microorganisms · 2021Article
- Assessment ofFrontiers in bioengineering and biotechnology · 2021Article
- The Protection ofFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Our previous study confirmed the ability of Lactobacillus plantarum CCFM8610 to protect against acute cadmium (Cd) toxicity in mice. This study was designed to evaluate the protective effects of CCFM8610 against chronic Cd toxicity in mice and to gain insights into the protection mode of this strain. Experimental mice were divided into two groups and exposed to Cd for 8 weeks via drinking water or intraperitoneal injection. Both groups were further divided into four subgroups, control, Cd only, CCFM8610 only, and Cd plus CCFM8610. Levels of Cd were measured in the feces, liver, and kidneys, and alterations of several biomarkers of Cd toxicity were noted. The results showed that when Cd was introduced orally, cotreatment with Cd and CCFM8610 effectively decreased intestinal Cd absorption, reduced Cd accumulation in tissue, alleviated tissue oxidative stress, reversed hepatic and renal damage, and ameliorated the corresponding histopathological changes. When Cd was introduced intraperitoneally, administration of CCFM8610 did not have an impact on tissue Cd accumulation or reverse the activities of antioxidant enzymes. However, CCFM8610 still offered protection against oxidative stress and reversed the alterations of Cd toxicity biomarkers and tissue histopathology. These results suggest that CCFM8610 is effective against chronic cadmium toxicity in mice. Besides intestinal Cd sequestration, CCFM8610 treatment offers direct protection against Cd-induced oxidative stress. We also provide evidence that the latter is unlikely to be mediated via protection against Cd-induced alteration of antioxidant enzyme activities.
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Registered trials
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