ArticlePsychopharmacology2014
Enriched environment prevents cognitive and motor deficits associated with postnatal MK-801 treatment.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Exergaming for dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2024Pooled it
- Article
- Correlation between desynchrony of hippocampal neural activity and hyperlocomotion in the model mice of schizophrenia and therapeutic effects of aripiprazole.CNS neuroscience & therapeutics · 2024Article
- Enriched environment as a nonpharmacological neuroprotective strategy.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Evaluation of Ayres Sensory IntegrationClinical medicine insights. Case reports · 2023Article
- Effect of prenatal different auditory environment on learning ability and fearfulness in chicks.Animal bioscience · 2022Article
- The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia.Frontiers in cellular neuroscience · 2022Review
- Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence.Molecular psychiatry · 2021Article
- Enriched Environment Reverts Somatostatin Interneuron Loss in MK-801 Model of Schizophrenia.Molecular neurobiology · 2020Article
- Effects of Intraperitoneal N-methyl-D-aspartate (NMDA) Administration on Nociceptive/Repetitive Behaviors in Juvenile Mice.Biomolecules & therapeutics · 2019Article
- Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory.Frontiers in aging neuroscience · 2018Article
- Short-Term Exposure to Enriched Environment in Adult Rats Restores MK-801-Induced Cognitive Deficits and GABAergic Interneuron Immunoreactivity Loss.Molecular neurobiology · 2018Article
- Postnatal Administration of Dizocilpine Inhibits Neuronal Excitability in PFC and Induces Social Deficits Detected by MiceProfiler.Molecular neurobiology · 2017Article
- Postnatal MK-801 treatment of female rats impairs acquisition of working memory, but not reference memory in an eight-arm radial maze; no beneficial effects of enriched environment.Psychopharmacology · 2015Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePrevious studies have shown the beneficial effects of enriched environment (EE) in rescuing behavioral deficits such as pre-pulse inhibition and locomotor hyperactivity associated with N-methyl-D-aspartate (NMDA) receptor blockade; however, cognitive deficits remain unresponsive.
objectivesWe designed experiments to determine the consequences of raising rat pups in an EE on several behavioral aberrations, mainly cognitive deficits, observed in rats postnatally exposed to MK-801 (NMDA receptor antagonist).
methodsMale Wistar rats were injected with MK-801 (1 mg/kg) from postnatal day (P) 6-10. Rat pups were housed in an EE from birth up to the time of behavioral experiments at P28-34. The effects of EE in correcting MK-801-associated behaviors were assessed by rotarod, wire grip, open filed, and Morris water maze tests.
resultsWe found that EE not only has beneficial effects on cognitive performance of normal rats but also prevents spatial learning and memory deficits in Morris water maze induced by MK-801. Postnatal MK-801 treatment also led to motor deficits both in wire grip and accelerating rotarod tests. These deficits were not observed in MK-801-treated rats raised in EE. In the open field test, EE prevented increase in "frequency of grooming" and decrease in "time spent in the center" associated with MK-801.
conclusionsOur results suggest that exposure to an EE would be strongly beneficial in correcting deficits, notably cognitive, associated with MK-801. Given that the postnatal MK-801 treatment represents an animal model of schizophrenia, we propose timely environmental interventions might be an effective strategy in the protection against schizophrenia.
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