ArticlePloS one2014
Effects of high intensity training and high volume training on endothelial microparticles and angiogenic growth factors.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Acute and chronic effects of high-intensity interval training on selected exerkine secretion in health, disease, and aging: a systematic review.Frontiers in physiology · 2025Pooled it
- Exercise and Circulating Microparticles in Healthy Subjects.Journal of cardiovascular translational research · 2021Pooled it
- Proteomic changes induced by acute exercise and high-intensity interval training during pregnancy: a pilot randomised controlled trial.Scientific reports · 2025Trial
- The effect of high-intensity interval training on inhibitory function in overweight female college students: the mediating role of body composition.BMC psychology · 2025Trial
- Exercise intensity regulates cytokine and klotho responses in men.Nutrition & diabetes · 2021Trial
- Exercise during hemodialysis does not affect the phenotype or prothrombotic nature of microparticles but alters their proinflammatory function.Physiological reports · 2018Trial
- Effect of 3-week high-intensity interval training on VO2max, total haemoglobin mass, plasma and blood volume in well-trained athletes.European journal of applied physiology · 2015Trial
- Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review).International journal of molecular medicine · 2026Review
- Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026Review
- Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).bioRxiv : the preprint server for biology · 2026Article
- Salivary vascular growth factor responses to prolonged and interrupted sitting in young, healthy adults.Physiological reports · 2026Article
- The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication.Exercise and sport sciences reviews · 2026Review
- Recreational Exercise and Inflammatory Patterns in Hashimoto's Thyroiditis: Observations from a Cross-Sectional Study.Biomolecules · 2025Observational
- Feasibility and acute physiological responses to supramaximal high-intensity interval training in COPD: a randomised crossover trial.ERJ open research · 2025Article
- Associations of active commuting and leisure-time physical activity with perceived cognitive function and work ability among Finnish employed adults: a population-based study.BMC public health · 2025Article
- The interplay of exercise and green tea: a new road in cancer therapy.Cancer cell international · 2025Review
- Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise.Journal of extracellular vesicles · 2024Article
- Correspondence: work smart or work hard in patients with metastatic breast cancer: emphasizing the importance of immunological and lactate changes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Are active school transport and leisure-time physical activity associated with performance and wellbeing at secondary school? A population-based study.European journal of public health · 2023Article
- Relationship of Endothelial Microparticles to Obesity and Cardiovascular Disease Risk in Children and Adolescents.Journal of the American Heart Association · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsEndothelial microparticles (EMP) are complex vesicular structures shed from activated or apoptotic endothelial cells. As endurance exercise affects the endothelium, the objective of the study was to examine levels of EMP and angiogenic growth factors following different endurance exercise protocols.
methods12 subjects performed 3 different endurance exercise protocols: 1. High volume training (HVT; 130 min at 55% peak power output (PPO); 2. 4 × 4 min at 95% PPO; 3. 4 × 30 sec all-out. EMPs were quantified using flow cytometry after staining platelet-poor-plasma. Events positive for Annexin-V and CD31, and negative for CD42b, were classified as EMPs. Vascular endothelial growth factor (VEGF), migratory inhibiting factor (MIF) and hepatocyte growth factor (HGF) were determined by ELISA technique. For all these measurements venous blood samples were taken pre, 0', 30', 60' and 180' after each intervention. Furthermore, in vitro experiments were performed to explore the effect of collected sera on target endothelial functions and MP uptake capacities.
resultsVEGF and HGF significantly increased after HIT interventions. All three interventions caused a significant decrease in EMP levels post exercise compared to pre values. The sera taken after exercise increased the uptake of EMP in target endothelial cells compared to sera taken under resting conditions, which was shown to be phosphatidylserin-dependent. Increased EMP uptake was associated with an improved protection of target cells against apoptosis. Sera taken prior and after exercise promoted target endothelial cell migration, which was abrogated after inhibition of VEGF.
conclusionPhysical exercise leads to decreased EMP levels and promotes a phosphatidylserin-dependent uptake of EMP into target endothelial cells, which is associated with a protection of target cells against apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.