ArticlePloS one2014
Inflammation and prolonged QT time: results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Systemic Inflammation Is Associated with Resting Premature Atrial and Ventricular Contractions in American Older Adults.The Journal of innovations in cardiac rhythm management · 2026Article
- A retrospective study of electrocardiographic alterations in primary Sjögren's syndrome: role of anti-SSA positivity and disease duration.Clinical rheumatology · 2025Observational
- Obesity Arrhythmias: Role of IL-6 Trans-Signaling.International journal of molecular sciences · 2024Review
- Fir(e)ing the Rhythm: Inflammatory Cytokines and Cardiac Arrhythmias.JACC. Basic to translational science · 2023Review
- Sex and gender differences in myocarditis and dilated cardiomyopathy: An update.Frontiers in cardiovascular medicine · 2023Review
- ECG characteristics of COVID-19 patient with arrhythmias: Referral hospitals data from Indonesia.Journal of arrhythmia · 2022Article
- Cardiovascular Disease in Primary Sjögren's Syndrome: Raising Clinicians' Awareness.Frontiers in immunology · 2022Review
- Correlation of inflammatory cytokines on corrected QT interval in rifampicin-resistant tuberculosis patients.Annals of medicine and surgery (2012) · 2021Article
- The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients.Endocrine connections · 2021Article
- ECG Markers of Cardiovascular Toxicity in Adult and Pediatric Cancer Treatment.Disease markers · 2021Review
- Abrogation of CC Chemokine Receptor 9 Ameliorates Ventricular Electrical Remodeling in Mice After Myocardial Infarction.Frontiers in cardiovascular medicine · 2021Article
- Neurological Disorders and Risk of Arrhythmia.International journal of molecular sciences · 2020Review
- Relation of total bilirubin and QT interval prolongation (from the Third National Health and Nutrition Examination Survey).Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Article
- Arrhythmogenic Inflammatory Cardiomyopathy in Autoimmune Rheumatic Diseases: A Challenge for Cardio-Rheumatology.Diagnostics (Basel, Switzerland) · 2019Review
- Emerging Arrhythmic Risk of Autoimmune and Inflammatory Cardiac Channelopathies.Journal of the American Heart Association · 2018Review
- Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.PloS one · 2018Article
- Nonalcoholic Fatty Liver Disease Is Associated With QT Prolongation in the General Population.Journal of the American Heart Association · 2015Observational
- Long QT Syndrome: An Emerging Role for Inflammation and Immunity.Frontiers in cardiovascular medicine · 2015Review
- Sex differences in inflammation during atherosclerosis.Clinical Medicine Insights. Cardiology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious research found an association of CRP with QT time in population based samples. Even more, there is evidence of a substantial involvement of the tumor necrosis factor-alpha system in the pathophysiology of cardiac arrhythmia, while the role of Interleukin 6 remains inconclusive.
objectiveTo determine the association between inflammation with an abnormally prolonged QT-time (APQT) in men and women of the elderly general population.
methodsData descend from the baseline examination of the prospective, population-based Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study. After exclusion of subjects with atrial fibrillation and missing ECG recording the final study cohort consisted of 919 men and 797 women. Blood parameters of inflammation were the soluble TNF-Receptor 1 (sTNF-R1), the high-sensitive C-reactive protein (hsCRP), and Interleukin 6 (IL-6). In accordance with major cardiologic societies we defined an APQT above a QT time of 460 ms in women and 450 ms in men. Effect sizes and the corresponding 95% confidence intervals (CI) were estimated by performing multiple linear and logistic regression analyses including the analysis of sex differences by interaction terms.
resultsAfter covariate adjustment we found an odds ratio (OR) of 1.89 (95% CI: 1.13, 3.17) per 1000 pg/mL increase of sTNF-R1 in women, and 0.74 (95% CI: 0.48, 1.15) in men. In the covariate adjusted linear regression sTNF-R1 was again positively associated with QT time in women (5.75 ms per 1000 pg/mL, 95% CI: 1.32, 10.18), but not in men. Taking possible confounders into account IL-6 and hsCRP were not significantly related to APQT in both sexes.
conclusionOur findings from cross-sectional analyses give evidence for an involvement of TNF-alpha in the pathology of APQT in women.
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