ArticleMolecular biology and evolution2014
A small system--high-resolution study of metabolic adaptation in the central metabolic pathway to temperate climates in Drosophila melanogaster.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation.bioRxiv : the preprint server for biology · 2024Article
- Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways.Metabolites · 2022Review
- STXBP3 and GOT2 predict immunological activity in acute allograft rejection.Frontiers in immunology · 2022Article
- A Tale of Two Transcriptomic Responses in Agricultural Pests via Host Defenses and Viral Replication.International journal of molecular sciences · 2021Article
- Genomic Responses to Climate Change: Making the Most of theFrontiers in genetics · 2021Article
- Spatiotemporal dynamics and genome-wide association genome-wide association analysis of desiccation tolerance in Drosophila melanogaster.Molecular ecology · 2018Article
- Adaptive self-organization in the embryo: its importance to adult anatomy and to tissue engineering.Journal of anatomy · 2018Review
- Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory.Nature communications · 2017Article
- On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.Scientific reports · 2017Article
- Ecological and genetic basis of metapopulation persistence of the Glanville fritillary butterfly in fragmented landscapes.Nature communications · 2017Article
- New views on the selection acting on genetic polymorphism in central metabolic genes.Annals of the New York Academy of Sciences · 2017Review
- Adaptive dynamics of cuticular hydrocarbons in Drosophila.Journal of evolutionary biology · 2017Article
- Cold adaptation increases rates of nutrient flow and metabolic plasticity during cold exposure in Drosophila melanogaster.Proceedings. Biological sciences · 2016Article
- Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster.Molecular ecology · 2016Article
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
- Flux Control in a Defense Pathway in Arabidopsis thaliana Is Robust to Environmental Perturbations and Controls Variation in Adaptive Traits.G3 (Bethesda, Md.) · 2015Article
- Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.G3 (Bethesda, Md.) · 2015Article
- Variation in Drosophila melanogaster central metabolic genes appears driven by natural selection both within and between populations.Proceedings. Biological sciences · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In this article, we couple the geographic variation in 127 single-nucleotide polymorphism (SNP) frequencies in genes of 46 enzymes of central metabolism with their associated cis-expression variation to predict latitudinal or climatic-driven gene expression changes in the metabolic architecture of Drosophila melanogaster. Forty-two percent of the SNPs in 65% of the genes show statistically significant clines in frequency with latitude across the 20 local population samples collected from southern Florida to Ontario. A number of SNPs in the screened genes are also associated with significant expression variation within the Raleigh population from North Carolina. A principal component analysis of the full variance-covariance matrix of latitudinal changes in SNP-associated standardized gene expression allows us to identify those major genes in the pathway and its associated branches that are likely targets of natural selection. When embedded in a central metabolic context, we show that these apparent targets are concentrated in the genes of the upper glycolytic pathway and pentose shunt, those controlling glycerol shuttle activity, and finally those enzymes associated with the utilization of glutamate and pyruvate. These metabolites possess high connectivity and thus may be the points where flux balance can be best shifted. We also propose that these points are conserved points associated with coupling energy homeostasis and energy sensing in mammals. We speculate that the modulation of gene expression at specific points in central metabolism that are associated with shifting flux balance or possibly energy-state sensing plays a role in adaptation to climatic variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.