Evidence map›Paper›PMID 24769796›Full record

ArticleChemical communications (Cambridge, England)2014

Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles.

Andrew G Cheetham, Yu-Chuan Ou, Pengcheng Zhang, Honggang Cui

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Article
  15. Self-assembling prodrugs.Chemical Society reviews · 2017
    Review
  16. Article
  17. Article
  18. Designing hydrogels for controlled drug delivery.Nature reviews. Materials · 2016
    Article
  19. Anticancer nanoparticulate polymer-drug conjugate.Bioengineering & translational medicine · 2016
    Review
  20. Macromolecules · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew G CheethamDepartment of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology (INBT), The Johns Hopkins University, Baltimore, MD 21218, USA. hcui6@jhu.edu.
Yu-Chuan Ou
Pengcheng Zhang
Honggang Cui

Funding

T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
T-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCMT32CA130840 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2008 to 2012
$1.2M
NCI NIH HHS T-32CA130840NCI NIH HHS T32 CA130840NCI NIH HHS T32 CA153952
6 · The paper itself

Abstract

We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.

Indexed as

Antineoplastic Agents, PhytogenicBreast NeoplasmsCamptothecinCell Line, TumorCell SurvivalDrug LiberationFemaleHumansMicroscopy, Electron, TransmissionNanostructuresProdrugstau ProteinsAntineoplastic Agents, PhytogenicCamptothecinProdrugstau Proteins

Identifiers

PMID24769796
PMCPMC4160079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.