Evidence map›Paper›PMID 24769692›Full record

SynthesisAnnals of oncology : official journal of the European Society for Medical Oncology2014

Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies.

D S M Chan, A R Vieira, D Aune, E V Bandera, D C Greenwood, A McTiernan, D Navarro Rosenblatt, I Thune, R Vieira, T Norat

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of oncology : official journal of the European Society for Medical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 661 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
661citing papers in PubMed, 9 pooled it
37.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06164119 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomised Effectiveness-implementation Trial for Evaluating Dietary and Manual Treatment With Osteopathic Techniques on Quality of Life and on Modulation of the Inflammatory State of Patients Diagnosed With Breast Cancer Undergoing Antiestrogenic Hormonal Treatment.

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2023 to 2025Enrolled600ConditionsBreast CancerArmsmanual treatment with osteopathic techniques and nutritional treatment, manual treatment with osteopathic techniques, nutritional treatment
NCT06860425 narecruitingnot on this mapstarted 2023, after this paper: background citation

Use of a Comprehensive, Mobile Application to Assist Cancer Patients With Diet, Nutrition and Activity

TypeinterventionalSponsorMontefiore Medical CenterRan2023 to 2027Enrolled50ConditionsMobile Applications, Cancer PatientsArmsRestoreMe
3 · Its place in the literature

Who cites it

661 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,145 citations in OpenAlex.

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  5. Body mass index and cancer survival: a meta-analysis of cohort studies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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  9. Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
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601 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

D S M ChanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Electronic address: d.chan@imperial.ac.uk.
A R VieiraDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
D AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK; Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
E V BanderaRutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Jersey, USA.
D C GreenwoodDivision of Biostatistics, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK.
A McTiernanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Washington, USA.
D Navarro RosenblattDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
I ThuneDepartment of Oncology, Oslo University Hospital, Oslo; Faculty of Health Sciences, Department of Community Medicine, University of Tromso, Tromso, Norway.
R VieiraSchool of Mathematics and Statistics, University of Newcastle, Newcastle upon Tyne, UK.
T NoratDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Imperial College London · GBFred Hutch Cancer Center · USNewcastle University · GBNorwegian University of Science and Technology · NOOslo University Hospital · NORutgers, The State University of New Jersey · USUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPositive association between obesity and survival after breast cancer was demonstrated in previous meta-analyses of published data, but only the results for the comparison of obese versus non-obese was summarised.

methodsWe systematically searched in MEDLINE and EMBASE for follow-up studies of breast cancer survivors with body mass index (BMI) before and after diagnosis, and total and cause-specific mortality until June 2013, as part of the World Cancer Research Fund Continuous Update Project. Random-effects meta-analyses were conducted to explore the magnitude and the shape of the associations.

resultsEighty-two studies, including 213 075 breast cancer survivors with 41 477 deaths (23 182 from breast cancer) were identified. For BMI before diagnosis, compared with normal weight women, the summary relative risks (RRs) of total mortality were 1.41 [95% confidence interval (CI) 1.29-1.53] for obese (BMI >30.0), 1.07 (95 CI 1.02-1.12) for overweight (BMI 25.0-<30.0) and 1.10 (95% CI 0.92-1.31) for underweight (BMI <18.5) women. For obese women, the summary RRs were 1.75 (95% CI 1.26-2.41) for pre-menopausal and 1.34 (95% CI 1.18-1.53) for post-menopausal breast cancer. For each 5 kg/m(2) increment of BMI before, <12 months after, and ≥12 months after diagnosis, increased risks of 17%, 11%, and 8% for total mortality, and 18%, 14%, and 29% for breast cancer mortality were observed, respectively.

conclusionsObesity is associated with poorer overall and breast cancer survival in pre- and post-menopausal breast cancer, regardless of when BMI is ascertained. Being overweight is also related to a higher risk of mortality. Randomised clinical trials are needed to test interventions for weight loss and maintenance on survival in women with breast cancer.

Indexed as

Body Mass IndexBreast NeoplasmsFemaleFollow-Up StudiesHumansMEDLINEObesityPrognosisRandomized Controlled Trials as TopicRisk FactorsSurvivorsbody mass indexmeta-analysissurvival after breast cancersystematic literature review

Identifiers

PMID24769692
PMCPMC4176449
OpenAlexW2149466392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.