ArticleAnatomy and embryology1989
The developing neuroepithelium in human embryonic and fetal brain studied with vimentin-immunocytochemistry.
Article in Anatomy and embryology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Cytological and Immunohistochemical Analysis of Human Fetal Brain across Different Gestational Ages.Maedica · 2026Article
- Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system.Nature communications · 2024Article
- The HOPX and BLBP landscape and gliogenic regions in developing human brain.Journal of anatomy · 2023Article
- Astrogliogenesis in human fetal brain: complex spatiotemporal immunoreactivity patterns of GFAP, S100, AQP4 and YKL-40.Journal of anatomy · 2019Review
- Central Nervous System and Vertebrae Development in Horses: a Chronological Study with Differential Temporal Expression of Nestin and GFAP.Journal of molecular neuroscience : MN · 2017Article
- Meninges harbor cells expressing neural precursor markers during development and adulthood.Frontiers in cellular neuroscience · 2015Article
- Emerging cerebral connectivity in the human fetal brain: an MR tractography study.Cerebral cortex (New York, N.Y. : 1991) · 2012Article
- Characterization of Porcine Ventral Mesencephalic Precursor Cells following Long-Term Propagation in 3D Culture.Stem cells international · 2012Article
- Genetic loci for ventricular dilatation in the LEW/Jms rat with fetal-onset hydrocephalus are influenced by gender and genetic background.Cerebrospinal fluid research · 2005Article
- Distribution patterns of vimentin-immunoreactive structures in the human prosencephalon during the second half of gestation.Journal of anatomy · 1999Article
- Fetal ventral mesencephalon of human and rat origin maintained in vitro and transplanted to 6-hydroxydopamine-lesioned rats gives rise to grafts rich in dopaminergic neurons.Experimental brain research · 1996Article
- Differential expression of N-CAM, vimentin and MAP1B during initial pathfinding of olfactory receptor neurons in the mouse embryo.Anatomy and embryology · 1995Article
- Intermediate filament typing of the human embryonic and fetal notochord.Cell and tissue research · 1995Article
- Expression of phosphorylated high molecular weight neurofilament protein (NF-H) and vimentin in human developing dorsal root ganglia and spinal cord.Histochemistry · 1993Article
- Immunocytochemical demonstration of nerve growth factor receptor (NGF-R) in developing human fetal teeth.Anatomy and embryology · 1993Article
- Cytokeratin expression and early lens development.Anatomy and embryology · 1992Article
- Continuous culture of neuronal cells from adult human olfactory epithelium.Journal of molecular neuroscience : MN · 1992Article
- Glial cell differentiation in neuron-free and neuron-rich regions. II. Early appearance of S-100 protein positive astrocytes in human fetal hippocampus.Anatomy and embryology · 1991Article
- Glial cell differentiation in neuron-free and neuron-rich regions. I. Selective appearance of S-100 protein in radial glial cells of the hippocampal fimbria in human fetuses.Anatomy and embryology · 1991Article
- Changes in glial cell markers in recent and old demyelinated lesions in central pontine myelinolysis.Acta neuropathologica · 1990Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuroepithelial cells, which constitute the primordium of the CNS, are potentially capable of generating neuronal and glial cell lineages concomitantly. The appearance and morphological development of vimentin-positive neuroepithelial cells in human embryonic and fetal brain (4-16 weeks) were studied with immunocytochemistry. In embryos aged 4-6 weeks, vimentin-reactivity was seen in all neuroepithelial cells, including those which exhibited mitotic figures. The distribution of reactivity changed according to a general developmental pattern, which commenced and proceeded temporally different in various regions of the CNS. All regions exhibited vimentin-positive neuroepithelial cells, the distribution and morphology of which gradually changed, resulting in lamination of the neural wall into two and subsequently three layers. The neocortex and midline raphe were the only regions to differ significantly from the general pattern. When reactivity to glial fibrillary acidic protein developed at 7-8 weeks, the distribution was very much like that of vimentin at the same stage. Reactivity to glial, neuronal and other cellular markers (S-100, neurofilament, neuron specific enolase, desmin, and cytokeratin) revealed different distributions. Although cells retaining vimentin beyond the ventricular zone stage are radial glial cells and presumptive fibrous astrocytes, it seems unlikely that vimentin is a marker for a distinct cell lineage during early CNS development. It is suggested that all neuroepithelial cells in vivo differentiate to a stage where they express vimentin, and that vimentin may have a functional role in cellular movements and during the interkinetic nuclear migration.
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