ReviewNeuroscience and biobehavioral reviews2014
Developmental studies of the hippocampus and hippocampal-dependent behaviors: insights from interdisciplinary studies and tips for new investigators.
Review in Neuroscience and biobehavioral reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- D-Fructose Exposure Impairs Neuronal Development in Mouse Neural Stem Cells.International journal of molecular sciences · 2026Article
- Adolescent nutritional influences on the brain: implications for eating behaviors.Neuropharmacology · 2025Review
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- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABAProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Impacts of age and environment on postnatal microglial activity: Consequences for cognitive function following early life adversity.PloS one · 2024Article
- Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities.Current biology : CB · 2023Article
- A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.Cell reports methods · 2023Article
- Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.Neurobiology of disease · 2023Article
- Prenatal alcohol and tetrahydrocannabinol exposure: Effects on spatial and working memory.Frontiers in neuroscience · 2023Article
- Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in human and rodent studies.Frontiers in neuroscience · 2023Review
- Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes.Neurobiology of aging · 2022Article
- Article
- Article
- Implication of folate deficiency in CYP2U1 loss of function.The Journal of experimental medicine · 2021Article
- Differential effects of alkaloids on memory in rodents.Scientific reports · 2021Article
- Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats.Iranian journal of basic medical sciences · 2021Article
- β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline.Frontiers in nutrition · 2021Article
- Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota.Scientific reports · 2020Article
- The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture of polychlorinated biphenyls.Current research in toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The hippocampus is not fully developed at birth and, with respect to spatial cognition, only begins to show signs of adult-like function at three postnatal weeks in rodents. Studying the developmental period spanning roughly two to four weeks of age permits an understanding of the neural framework necessary for the emergence of spatial navigation and, quite possibly, human episodic memory. However, due to developmental factors, behavior data collection and interpretation can be severely compromised if inappropriate designs are applied. As such, we propose methodological considerations for the behavioral assessment of hippocampal function in developing rats that take into account animal size, growth rate, and sensory and motor ability. We further summarize recent key interdisciplinary studies that are beginning to unravel the molecular machinery and physiological alterations responsible for hippocampal maturation. In general, hippocampal development is a protracted process during which unique contributions to spatial cognition and complex recognition memory come "on line" at different postnatal ages creating a unique situation for elucidating the neural bases of specific components of higher cognitive abilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.