Evidence map›Paper›PMID 24769175›Full record

Trial reportInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2014

Relationship of vitamin D insufficiency to AIDS-associated Kaposi's sarcoma outcomes: retrospective analysis of a prospective clinical trial in Zimbabwe.

Kristine M Erlandson, Ivy Gudza, Suzanne Fiorillo, Buxton Ndemera, Robert T Schooley, Lovemore Gwanzura, Margaret Borok, Thomas B Campbell

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Immune Modulatory Effects of Vitamin D on Herpesvirus Infections.International journal of molecular sciences · 2025
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kristine M ErlandsonDepartment of Medicine, Division of Infectious Diseases, University of Colorado Denver, 12700 E. 19(th) Avenue, Mail Stop B168, Aurora, CO 80045, USA. Electronic address: Kristine.Erlandson@ucdenver.edu.
Ivy GudzaDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Suzanne FiorilloDepartment of Medicine, Division of Infectious Diseases, University of Colorado Denver, 12700 E. 19(th) Avenue, Mail Stop B168, Aurora, CO 80045, USA.
Buxton NdemeraDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Robert T SchooleyDepartment of Medicine, Division of Infectious Diseases, University of California San Diego, La Jolla, California, USA.
Lovemore GwanzuraDepartment of Medical Laboratory Sciences, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Margaret BorokDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe.
Thomas B CampbellDepartment of Medicine, Division of Infectious Diseases, University of Colorado Denver, 12700 E. 19(th) Avenue, Mail Stop B168, Aurora, CO 80045, USA.
University of Zimbabwe · ZWUniversity of Colorado Denver · USUniversity of California, San Diego · US

Funding

UNIVERSITY OF COLORADO HIV RESEARCH TRAINING PROGRAMT32AI007447 · NIAID · UNIVERSITY OF COLORADO DENVER · PI CAMPBELL, THOMAS B. · 1992 to 2016
$2.8M
NIAID NIH HHS T32 AI007447PHS HHS T32 A1007447-1
6 · The paper itself

Abstract

objectivesThe prevalence of vitamin D insufficiency in Africans with AIDS-associated Kaposi sarcoma (AIDS-KS) and the role of vitamin D in AIDS-KS progression are unknown. We hypothesized that a high prevalence of vitamin D deficiency would be found in Zimbabweans with AIDS-KS and that low baseline vitamin D would correlate with progression of AIDS-KS.

methodsNinety subjects were enrolled in a prospective pilot study investigation of the effect of antiretroviral therapy in the treatment of AIDS-KS in Harare, Zimbabwe. Co-formulated abacavir, lamivudine, and zidovudine was initiated; chemotherapy was provided at the discretion of the provider. Participants were followed for 96 weeks. 25-Hydroxyvitamin D was measured in stored specimens collected at study entry. The relationship between vitamin D and clinical response was described by odds ratio and 95% confidence interval.

resultsSamples were available for 85 participants; 45 (53%) subjects had inadequate (<75 nmol/l) 25-hydroxyvitamin D. HIV-1 RNA was significantly higher among those with insufficient vitamin D (4.7 vs. 4.5 log, p = 0.04). Tumor response, survival, and KS-IRIS were not associated with vitamin D (p ≥ 0.3).

conclusionsVitamin D insufficiency was common among Zimbabweans with AIDS-KS but not associated with outcomes after initiation of antiretroviral therapy.

Indexed as

AbacavirAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsDideoxynucleosidesDisease ProgressionFemaleHerpesvirus 8, HumanHIV-1HumansLamivudineMaleMiddle AgedOdds RatioPilot ProjectsProspective Studies25-hydroxyvitamin DAbacavirAnti-HIV AgentsDideoxynucleosidesLamivudineRNA, ViralVitamin DZidovudineAIDS-KSHIVVitamin D insufficiency

Identifiers

PMID24769175
PMCPMC4070314
OpenAlexW1991790625

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.