ReviewJournal of pediatric urology2014
The power and perils of animal models with urogenital anomalies: handle with care.
Review in Journal of pediatric urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Gubernaculum and Epididymo-Testicular Descent: Review of the Literature.Acta medica Lituanic · 2022Review
- Expression of androgen, estrogen, and progesterone hormone receptors in the penile tissues of children with different types of hypospadias.Northern clinics of Istanbul · 2019Article
- Regulation of testicular descent.Pediatric surgery international · 2015Review
- A Comprehensive Atlas of the Adult Mouse Penis.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2015Article
- Diethylstilbestrol-induced mouse hypospadias: "window of susceptibility".Differentiation; research in biological diversityReview
- Immunohistochemical expression analysis of the human fetal lower urogenital tract.Differentiation; research in biological diversityArticle
- The embryology of persistent cloaca and urogenital sinus malformations.Asian journal of andrologyReview
- Androgen and estrogen receptor expression in the developing human penis and clitoris.Differentiation; research in biological diversityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Congenital abnormalities of the urogenital tracts form a major part of clinical practice for paediatric urologists, but their knowledge of normal and abnormal development is often limited. Advances in understanding frequently come from studying experimental findings from animal models, however, most clinicians underestimate both the power and perils of extrapolating scientific knowledge from animals. In this review, the key issues that urologists need to understand in order to link animal studies to clinical practice are discussed. Urologists must avoid the traps of anthropomorphism (assuming humans are always the same as animal models) or anthropocentrism (assuming humans are too different from animal models). This review used two common disorders: hypospadias and undescended testes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.