Evidence map›Paper›PMID 24768440›Full record

ArticleSchizophrenia research2014

Genetic influences on cognitive endophenotypes in schizophrenia.

Ronald A Yeo, Steven W Gangestad, Esther Walton, Stefan Ehrlich, Jessica Pommy, Jessica A Turner, Jingyu Liu, Andrew R Mayer, S Charles Schulz, Beng-Choon Ho and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ronald A YeoDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA; The Mind Research Network, Albuquerque, NM, USA. Electronic address: ryeo@unm.edu.
Steven W GangestadDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Esther WaltonMGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden, Germany; Dresden University of Technology, Dresden, Germany.
Stefan EhrlichMGH/MIT/HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden, Germany; Dresden University of Technology, Dresden, Germany; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Jessica PommyDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Jessica A TurnerThe Mind Research Network, Albuquerque, NM, USA; Dept. of Psychology, Georgia State University, Atlanta, GA, USA; Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
Jingyu LiuThe Mind Research Network, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA.
Andrew R MayerThe Mind Research Network, Albuquerque, NM, USA.
S Charles SchulzDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Beng-Choon HoDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Juan R BustilloThe Mind Research Network, Albuquerque, NM, USA; Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.
Thomas H WassinkDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Scott R SponheimDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA; Minneapolis Veterans Administration Health Care System, Minneapolis, MN, USA.
Eric M MorrowDepartment of Molecular Biology, Cell Biology and Biochemistry, Laboratory for Molecular Medicine, Brown University, Providence, RI, USA.
Vince D CalhounThe Mind Research Network, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA.

Funding

Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
NEURAL MECHANISMS OF SCHIZOPHRENIAP20RR021938 · NCRR · THE MIND RESEARCH NETWORK · PI JUNG, REX · 2008 to 2011
$9.4M
Informed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5M
A Multidimensional Investigation of Cognitive Control Deficits in PsychopathologyR01MH101512 · NIMH · THE MIND RESEARCH NETWORK · PI MAYER, ANDREW ROBERT · 2014 to 2017
$2.8M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
Genetic markers of white matter integrity in schizophrenia: Relationship to cliniRC1MH089257 · NIMH · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2009 to 2010
$985k
NCRR NIH HHS 5P20RR021938NCRR NIH HHS P20 RR021938NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIMH NIH HHS 1RC1MH089257NIMH NIH HHS R01 MH101512NIMH NIH HHS RC1 MH089257
6 · The paper itself

Abstract

backgroundCognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research.

methodsThe current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), and one based on single nucleotide polymorphisms identified in recent risk studies (genetic risk score). The impact of these genetic factors, and their interaction, was examined on cognitive endophenotypes defined by principal component analysis (PCA) in a multi-center sample of 50 patients with schizophrenia and 86 controls. PCA was used to identify three different types of executive function (EF: planning, fluency, and inhibition), and in separate analyses, a measure general cognitive ability (GCA).

resultsCognitive deficits were prominent among individuals with schizophrenia, but no group differences were evident for either genetic factor. Among patients the deletion burden measures predicted cognitive deficits across the three EF components and GCA. Further, an interaction was noted between the two genetic factors for both EF and GCA and the observed patterns of interaction suggested antagonistic epistasis. In general, the set of genetic interactions examined predicted a substantial portion of variance in these cognitive endophenotypes. LIMITATIONS: Though adequately powered, our sample size is small for a genetic study.

conclusionsThese results draw attention to genetic interactions and the possibility that genetic influences on cognition differ in patients and controls.

Indexed as

EndophenotypesAdultAnalysis of VarianceCognition DisordersFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleNeuropsychological TestsPrincipal Component AnalysisPsychiatric Status Rating ScalesSchizophreniaYoung AdultCognitiveEndophenotypeExecutive functionGeneticsMutationSchizophrenia

Identifiers

PMID24768440
PMCPMC4699552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.