Observational studyJournal of vascular surgery2014
Trends in the incidence, treatment, and outcomes of acute lower extremity ischemia in the United States Medicare population.
Observational study in Journal of vascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vascular Quality Initiative (VQI) - Data Extraction and Longitudinal Trend Analysis (DELTA) Paclitaxel Device Safety Analysis - Phase I Study
Vascular Implant Surveillance and Interventional Outcomes Network and the Vascular Quality Initiative Paclitaxel Safety Analysis
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Guideline
- Surgery versus thrombolysis for initial management of acute limb ischaemia.The Cochrane database of systematic reviews · 2018Pooled it
- Prospective Single-Arm Trial of Endovascular Mechanical Debulking as Initial Therapy in Patients With Acute and Subacute Lower Limb Ischemia: One-Year Outcomes.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2019Trial
- Open or endovascular revascularization in the treatment of acute lower limb ischaemia.The British journal of surgery · 2018Trial
- Treatment of Acute Lower-Extremity Arterial Occlusions With a Combined Mechanical and Aspiration Thrombectomy System.JACC. Case reports · 2025Article
- Comparison of open and endovascular therapy for infrainguinal acute limb ischemia in the era of percutaneous thrombectomy.Journal of vascular surgery · 2025Article
- Out-of-pocket health care spending among patients with acute limb ischemia stratified by income.Journal of vascular surgery · 2025Article
- One-year clinical outcomes of endovascular revascularization in patients with acute limb ischemia.Heart and vessels · 2025Article
- Noninvasive monitoring of vascular alterations in mice with acute lower limb ischemia using multimodal photoacoustic imaging.Bioengineering & translational medicine · 2025Article
- Misdiagnosis of Acute Limb Ischemia from Non-Vascular Specialists Results in a Delayed Presentation and Negatively Affects Patients' Outcomes.Medical sciences (Basel, Switzerland) · 2025Article
- Contemporary National Incidence and Outcomes of Acute Limb Ischemia.Annals of vascular surgery · 2025Article
- Acute limb ischemia in the elderly: Determining the mortality factors.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Temporal trends in lower extremity amputation in Middle East and North Africa (MENA) region: analysis of the GBD dataset 1990-2019.International journal for equity in health · 2024Article
- Prospective multicentre observational study evaluating acute lower limb ischaemia (PROMOTE-ALI).The British journal of surgery · 2024Observational
- Molecular Insight into Acute Limb Ischemia.Biomolecules · 2024Review
- Percutaneous thrombectomy for acute limb ischemia is associated with equivalent limb and mortality outcomes compared with open thrombectomy.Journal of vascular surgery · 2024Article
- Management of Acute Lower Limb Ischemia Without Surgical Revascularization - A Population-Based Study.Vascular and endovascular surgery · 2024Article
- Article
- Acute limb ischemia.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAcute lower extremity ischemia (ALI) is a common vascular surgery emergency associated with high rates of morbidity and mortality. The purpose of this study was to assess contemporary trends in the incidence of ALI, the methods of treatment, and the associated mortality and amputation rates in the U.S. Medicare population.
methodsThis was an observational study using Medicare claims data between 1998 and 2009. Outcomes examined included trends in the incidence of ALI; trends in interventions for ALI; and trends in amputation, mortality, and amputation-free survival rates.
resultsBetween 1998 and 2009, the incidence of hospitalization for ALI decreased from 45.7 per 100,000 to 26.0 per 100,000 (P for trend < .001). The percentage of patients undergoing surgical intervention decreased from 57.1% to 51.6% (P for trend < .001), whereas the percentage of patients undergoing endovascular interventions increased from 15.0% to 33.1% (P for trend < .001). In-hospital mortality rates decreased from 12.0% to 9.0% (P for trend < .001), whereas 1-year mortality rates remained stable at 41.0% and 42.5% (P for trend not significant). In-hospital amputation rates remained stable at 8.1% and 6.4% (P for trend not significant), whereas 1-year amputation rates decreased from 14.8% to 11.0% (P for trend < .001). In-hospital amputation-free survival after hospitalization for ALI increased from 81.2% to 85.4% (P for trend < .001); however, 1-year amputation-free survival remained unchanged.
conclusionsBetween 1998 and 2009, the incidence of ALI among the U.S. Medicare population declined significantly, and the percentage of patients treated with endovascular techniques markedly increased. During this time, 1-year amputation rates declined. Furthermore, although in-hospital mortality rates declined after presentation with ALI, 1-year mortality rates remained unchanged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.