Evidence map›Paper›PMID 24768271›Full record

ArticleSocial science & medicine (1982)2014

Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors? A twin study.

Mia Madsen, Per K Andersen, Mette Gerster, Anne-Marie N Andersen, Kaare Christensen, Merete Osler

Abstract readTwin Study
PubMed Publisher
In one paragraph

Article in Social science & medicine (1982), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  5. Educational Influences on Late-Life Health: Genetic Propensity and Attained Education.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mia MadsenUnit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, J.B. Winsløwsvej 9B, 5000 Odense, Denmark; The Danish Twin Registry, University of Southern Denmark, J.B. Winsløwsvej 9B, Odense, Denmark; Danish Aging Research Center, University of Southern Denmark, J.B. Winsløwsvej 9B, Odense, Denmark. Electronic address: Mimadsen@health.sdu.dk.
Per K AndersenDepartment of Public Health, Section of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, Denmark. Electronic address: pkan@sund.ku.dk.
Mette GersterUnit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, J.B. Winsløwsvej 9B, 5000 Odense, Denmark. Electronic address: mgerster@gmail.dk.
Anne-Marie N AndersenDepartment of Public Health, Section of Social Medicine, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, Denmark. Electronic address: amny@sund.ku.dk.
Kaare ChristensenUnit of Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, J.B. Winsløwsvej 9B, 5000 Odense, Denmark; The Danish Twin Registry, University of Southern Denmark, J.B. Winsløwsvej 9B, Odense, Denmark; Danish Aging Research Center, University of Southern Denmark, J.B. Winsløwsvej 9B, Odense, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Sdr. Boulevard 29, Odense, Denmark; Department of Clinical Genetics, Odense University Hospital, Sdr. Boulevard 29, Odense, Denmark. Electronic address: kchristensen@health.sdu.dk.
Merete OslerDanish Aging Research Center, University of Southern Denmark, J.B. Winsløwsvej 9B, Odense, Denmark; Department of Public Health, Section of Social Medicine, University of Copenhagen, Øster Farimagsgade 5, Copenhagen, Denmark; Research Centre for Prevention and Health, Glostrup University Hospital, Nordre Ringvej 57, 84-85, Glostrup, Denmark. Electronic address: merete.osler@regionh.dk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To isolate the effect of education from the influence of potential underlying factors, we investigated the association of education with the risk of cardiovascular disease (CVD) and ischemic heart disease (IHD) using twin data to adjust for familial factors shared within twins, including genetic make-up and childhood environment. The study was based on data from the Danish Twin Registry linked to administrative and heath registers in Statistics Denmark. A total of 11,968 monozygotic and 20,464 dizygotic same sexed twins were followed from 1980 to 2009, including more than 8000 events of CVD. Unpaired and intra-pair analyses were compared. In the unpaired analyses, an inverse educational gradient in CVD- and IHD risk was observed. This association was not replicated in the intra-pair analyses that control for shared familial factors exploiting that twins share their intrauterine- and childhood environment and are matched partly or fully on genetic setup. The attenuation of association of education with CVD and IHD in the intra-pair analyses suggests that shared familial factors account for a substantial part of the observed association of education with CVD and IHD in Denmark.

Indexed as

EnvironmentGenetic Predisposition to DiseaseAdultCardiovascular DiseasesDenmarkEducational StatusFemaleHumansIncidenceMaleMyocardial IschemiaRisk FactorsSocioeconomic FactorsTwins, DizygoticTwins, MonozygoticCardiovascular diseasesEducationSocial classTwin Study

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.