ArticleSchizophrenia research2014
The relationship between default mode network connectivity and social functioning in individuals at familial high-risk for schizophrenia.
Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Familial Risk for Schizophrenia vs Bipolar Disorder and Task-Based Neural Activation: A functional Magnetic Resonance Imaging Meta-Analysis.Schizophrenia bulletin · 2024Pooled it
- Adding Sarcosine to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex.International journal of molecular sciences · 2015Trial
- Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability.Molecular psychiatry · 2025Article
- Impact of schizophrenia-associated risk genes on brain functional networks and executive deficits: a study of individuals with schizophrenia and genetic high risk.Psychological medicine · 2025Article
- Disentangling shared and unique brain functional changes associated with clinical severity and cognitive phenotypes in schizophrenia via deep learning.Communications biology · 2025Article
- Heterogeneity of morphometric similarity networks in health and schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Neural signatures of default mode network subsystems in first-episode, drug-naive patients with major depressive disorder after 6-week thought induction psychotherapy treatment.Brain communications · 2024Article
- The location of emotional intelligence measured by EQ-i in the personality and cognitive space: Are there gender differences?Frontiers in psychology · 2022Article
- Abnormal network homogeneity of default-mode network and its relationships with clinical symptoms in antipsychotic-naïve first-diagnosis schizophrenia.Frontiers in neuroscience · 2022Article
- The representation of mental state information in schizophrenia and first-degree relatives: a multivariate pattern analysis of fMRI data.Social cognitive and affective neuroscience · 2021Article
- Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors.Human brain mapping · 2020Article
- The Resting Brain Sets Support-Giving in Motion: Dorsomedial Prefrontal Cortex Activity During Momentary Rest Primes Supportive Responding.Cerebral cortex communications · 2020Article
- Individual variation in brain network topology is linked to emotional intelligence.NeuroImage · 2019Article
- Default Mode Network Connectivity Predicts Emotion Recognition and Social Integration After Traumatic Brain Injury.Frontiers in neurology · 2019Article
- fMRI biomarkers of social cognitive skills training in psychosis: Extrinsic and intrinsic functional connectivity.PloS one · 2019Article
- Resting state connectivity dynamics in individuals at risk for psychosis.Journal of abnormal psychology · 2018Article
- Weak dorsolateral prefrontal response to social criticism predicts worsened mood and symptoms following social conflict in people at familial risk for schizophrenia.NeuroImage. Clinical · 2018Article
- Shared atypical default mode and salience network functional connectivity between autism and schizophrenia.Autism research : official journal of the International Society for Autism Research · 2017Article
- Default mode functional connectivity is associated with social functioning in schizophrenia.Journal of abnormal psychology · 2017Article
- The social brain network in 22q11.2 deletion syndrome: a diffusion tensor imaging study.Behavioral and brain functions : BBF · 2017Article
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Authors and funding
3 authors.
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Abstract
Unaffected first-degree relatives of individuals with schizophrenia (i.e., those at familial high-risk [FHR]), demonstrate social dysfunction qualitatively similar though less severe than that of their affected relatives. These social difficulties may be the consequence of genetically conferred disruption to aspects of the default mode network (DMN), such as the dMPFC subsystem, which overlaps with the network of brain regions recruited during social cognitive processes. In the present study, we investigate this possibility, testing DMN connectivity and its relationship to social functioning in FHR using resting-state fMRI. Twenty FHR individuals and 17 controls underwent fMRI during a resting-state scan. Hypothesis-driven functional connectivity analyses examined ROI-to-ROI correlations between the DMN's hubs, and regions of the dMPFC subsystem and MTL subsystem. Connectivity values were examined in relationship to a measure of social functioning and empathy/perspective-taking. Results demonstrate that FHR exhibit reduced connectivity specifically within the dMPFC subsystem of the DMN. Certain ROI-to-ROI correlations predicted aspects of social functioning and empathy/perspective-taking across all participants. Together, the data indicate that disruption to the dMPFC subsystem of the DMN may be associated with familial risk for schizophrenia, and that these intrinsic connections may carry measurable consequences for social functioning.
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