Trial reportParkinsonism & related disorders2014
Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease.
Trial report in Parkinsonism & related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Research status and hotspots in the surgical treatment of tremor in Parkinson's disease from 2002 to 2022: a bibliometric and visualization analysis.Frontiers in aging neuroscience · 2023Pooled it
- Suicide in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2019Pooled it
- Patients' experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis.BMJ open · 2016Pooled it
- Medical device-based neuromodulation for motor symptoms in Parkinson's disease: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Connectivity Profile for Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson Disease.Annals of neurology · 2023Trial
- Long-term neuropsychological outcomes of deep brain stimulation in early-stage Parkinson's disease.Parkinsonism & related disorders · 2023Trial
- Early subthalamic nucleus deep brain stimulation in Parkinson's disease reduces long-term medication costs.Clinical neurology and neurosurgery · 2021Trial
- Trial
- Quality of life predicts outcome of deep brain stimulation in early Parkinson disease.Neurology · 2019Trial
- Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease.Neurology · 2018Trial
- Subthalamic Nucleus Deep Brain Stimulation May Reduce Medication Costs in Early Stage Parkinson's Disease.Journal of Parkinson's disease · 2016Trial
- 2024 Japan Society for Stereotactic and Functional Neurosurgery Guidelines for Stereotactic and Functional Neurosurgery.Neurologia medico-chirurgica · 2026Article
- Early-Onset Parkinson's Disease: Unique Features and Management Approaches.Current neurology and neuroscience reports · 2025Review
- Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson's disease: A Chinese retrospective multicenter cohort study.PLoS medicine · 2025Article
- Ameliorating motor performance and quality of life in Parkinson's disease: a comparison of deep brain stimulation and focused ultrasound surgery.Frontiers in neurology · 2025Review
- A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD.Open medicine (Warsaw, Poland) · 2025Review
- A framework for translational therapy development in deep brain stimulation.NPJ Parkinson's disease · 2024Review
- Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024Article
- How to Use the New European Academy of Neurology/Movement Disorder Society European Section Guideline for Invasive Therapies in Parkinson's Disease.Movement disorders clinical practice · 2024Review
- Deep brain stimulation for Parkinson's disease: systematic review with meta-analysis and trial sequential analysis.BMJ medicine · 2024Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundDeep brain stimulation (DBS) is an effective and approved therapy for advanced Parkinson's disease (PD), and a recent study suggests efficacy in mid-stage disease. This manuscript reports the results of a pilot trial investigating preliminary safety and tolerability of DBS in early PD.
methodsThirty subjects with idiopathic PD (Hoehn & Yahr Stage II off medication), age 50-75, on medication ≥6 months but ≤4 years, and without motor fluctuations or dyskinesias were randomized to optimal drug therapy (ODT) (n = 15) or DBS + ODT (n = 15). Co-primary endpoints were the time to reach a 4-point worsening from baseline in the UPDRS-III off therapy and the change in levodopa equivalent daily dose from baseline to 24 months.
resultsAs hypothesized, the mean UPDRS total and part III scores were not significantly different on or off therapy at 24 months. Medication requirements in the DBS + ODT group were lower at all time points with a maximal difference at 18 months. With a few exceptions, differences in neuropsychological functioning were not significant. Two subjects in the DBS + ODT group suffered serious adverse events; remaining adverse events were mild or transient.
conclusionsThis study demonstrates that subjects with early stage PD will enroll in and complete trials testing invasive therapies and provides preliminary evidence that DBS is well tolerated in early PD. The results of this trial provide the data necessary to design a large, phase III, double-blind, multicenter trial investigating the safety and efficacy of DBS in early PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.