ArticleCurrent biology : CB2014
Candidate neural substrates for off-edge motion detection in Drosophila.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed, 127 citations in OpenAlex.
- Article
- Bio-Inspired Motion-Contour-Guided Visual System for Contrast-Independent Looming Perception.Biomimetics (Basel, Switzerland) · 2026Article
- RNA-RNA interactions coordinate GABA metabolism and signaling.bioRxiv : the preprint server for biology · 2025Article
- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
- A Bio-Inspired Visual Neural Model for Robustly and Steadily Detecting Motion Directions of Translating Objects Against Variable Contrast in the Figure-Ground and Noise Interference.Biomimetics (Basel, Switzerland) · 2025Article
- Article
- Neural pathways and computations that achieve stable contrast processing tuned to natural scenes.Nature communications · 2024Article
- Heterogeneity of synaptic connectivity in the fly visual system.Nature communications · 2024Article
- Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila.Nature communications · 2023Article
- Neural mechanisms to incorporate visual counterevidence in self-movement estimation.Current biology : CB · 2023Article
- Neural mechanisms to incorporate visual counterevidence in self motion estimation.bioRxiv : the preprint server for biology · 2023Article
- Article
- Article
- Synaptic targets of photoreceptors specialized to detect color and skylight polarization ineLife · 2021Article
- The physiological basis for contrast opponency in motion computation in Drosophila.Nature communications · 2021Article
- TheG3 (Bethesda, Md.) · 2020Article
- How fly neurons compute the direction of visual motion.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Neuromodulation of insect motion vision.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Color vision in insects: insights from Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Better Sleep at Night: How Light Influences Sleep inFrontiers in physiology · 2020Review
1 more citing papers are in PubMed but not listed here.
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6 authors at 2 institutions in 2 countries.
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Abstract
backgroundIn the fly's visual motion pathways, two cell types-T4 and T5-are the first known relay neurons to signal small-field direction-selective motion responses [1]. These cells then feed into large tangential cells that signal wide-field motion. Recent studies have identified two types of columnar neurons in the second neuropil, or medulla, that relay input to T4 from L1, the ON-channel neuron in the first neuropil, or lamina, thus providing a candidate substrate for the elementary motion detector (EMD) [2]. Interneurons relaying the OFF channel from L1's partner, L2, to T5 are so far not known, however.
resultsHere we report that multiple types of transmedulla (Tm) neurons provide unexpectedly complex inputs to T5 at their terminals in the third neuropil, or lobula. From the L2 pathway, single-column input comes from Tm1 and Tm2 and multiple-column input from Tm4 cells. Additional input to T5 comes from Tm9, the medulla target of a third lamina interneuron, L3, providing a candidate substrate for L3's combinatorial action with L2 [3]. Most numerous, Tm2 and Tm9's input synapses are spatially segregated on T5's dendritic arbor, providing candidate anatomical substrates for the two arms of a T5 EMD circuit; Tm1 and Tm2 provide a second. Transcript profiling indicates that T5 expresses both nicotinic and muscarinic cholinoceptors, qualifying T5 to receive cholinergic inputs from Tm9 and Tm2, which both express choline acetyltransferase (ChAT).
conclusionsWe hypothesize that T5 computes small-field motion signals by integrating multiple cholinergic Tm inputs using nicotinic and muscarinic cholinoceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.