ArticleJournal of cataract and refractive surgery2014
Serial biomechanical comparison of edematous, normal, and collagen crosslinked human donor corneas using optical coherence elastography.
Article in Journal of cataract and refractive surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fetal membrane imaging and the prediction of preterm birth: a systematic review, current issues, and future directions.BMC pregnancy and childbirth · 2016Pooled it
- Effects of corneal cross-linking on ocular response analyzer waveform-derived variables in keratoconus and postrefractive surgery ectasia.Eye & contact lens · 2014Trial
- Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021Review
- Depth-resolved Corneal Biomechanical Changes Measured Via Optical Coherence Elastography Following Corneal Crosslinking.Translational vision science & technology · 2021Article
- Compressional Optical Coherence Elastography of the Cornea.Photonics · 2021Article
- Corneal biomechanics: Measurement and structural correlations.Experimental eye research · 2021Review
- Depth-Dependent Corneal Biomechanical Properties in Normal and Keratoconic Subjects by Optical Coherence Elastography.Translational vision science & technology · 2020Article
- A clinical method for estimating the modulus of elasticity of the human cornea in vivo.PloS one · 2020Article
- Ocular Pulse Elastography: Imaging Corneal Biomechanical Responses to Simulated Ocular Pulse Using Ultrasound.Translational vision science & technology · 2020Article
- Line-Field Optical Coherence Tomography as a tool for In vitro characterization of corneal biomechanics under physiological pressures.Scientific reports · 2019Article
- Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis.Journal of biophotonics · 2019Article
- Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography.Investigative ophthalmology & visual science · 2019Article
- A Review of Structural and Biomechanical Changes in the Cornea in Aging, Disease, and Photochemical Crosslinking.Frontiers in bioengineering and biotechnology · 2019Review
- Quantifying the effects of hydration on corneal stiffness with noncontact optical coherence elastography.Journal of cataract and refractive surgery · 2018Article
- Effects of Thickness on Corneal Biomechanical Properties Using Optical Coherence Elastography.Optometry and vision science : official publication of the American Academy of Optometry · 2018Article
- Imaging Corneal Biomechanical Responses to Ocular Pulse Using High-Frequency Ultrasound.IEEE transactions on medical imaging · 2018Article
- Live human assessment of depth-dependent corneal displacements with swept-source optical coherence elastography.PloS one · 2018Article
- 3D Characterization of corneal deformation using ultrasound speckle tracking.Journal of innovative optical health sciences · 2017Article
- Optical coherence elastography for evaluating customized riboflavin/UV-A corneal collagen crosslinking.Journal of biomedical optics · 2017Article
- Optical coherence elastography - OCT at work in tissue biomechanics [Invited].Biomedical optics express · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeTo noninvasively evaluate the effects of corneal hydration and collagen crosslinking (CXL) on the mechanical behavior of the cornea.
settingCleveland Clinic Cole Eye Institute, Cleveland, Ohio, USA.
designExperimental study.
methodsAn optical coherence elastography (OCE) technique was used to measure the displacement behavior of 5 pairs of debrided human donor globes in 3 serial states as follows: edematous, normal thickness, and after riboflavin-ultraviolet-A-mediated CXL. During micromotor-controlled axial displacements with a curved goniolens at physiologic intraocular pressure (IOP), serial optical coherence tomography scans were obtained to allow high-resolution intrastromal speckle tracking and displacement measurements over the central 4.0 mm of the cornea.
resultsWith no imposed increase in IOP, the mean lateral to imposed axial displacement ratios were 0.035 μm/μm ± 0.037 (SD) in edematous corneas, 0.021 ± 0.02 μm/μm in normal thickness corneas, and 0.014 ± 0.009 μm/μm in post-CXL corneas. The differences were statistically significant (P<.05, analysis of variance) and indicated a 40% increase in lateral stromal resistance with deturgescence and a further 33% mean increase in relative stiffness with CXL.
conclusionsSerial perturbations of the corneal hydration state and CXL had significant effects on corneal biomechanical behavior. With an axially applied stress from a nonapplanating contact lens, displacements along the direction of the collagen lamellae were 2 orders of magnitude lower than axial deformations. These experiments show the ability of OCE to quantify clinically relevant mechanical property differences under physiologic conditions. FINANCIAL DISCLOSURES: Proprietary or commercial disclosures are listed after the references.
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