Evidence map›Paper›PMID 24767715›Full record

ReviewBurns : journal of the International Society for Burn Injuries2014

Up-to-date approach to manage keloids and hypertrophic scars: a useful guide.

Anna I Arno, Gerd G Gauglitz, Juan P Barret, Marc G Jeschke

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Burns : journal of the International Society for Burn Injuries, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04532840 (Effect of Cryotherpy on Hypertrophic Scar), which is not on this map. Cited by 156 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 10 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04532840 phase2 / phase3unknown statusnot on this mapstarted 2019, after this paper: background citation

Effect of Cryotherpy on Hypertrophic Scar

TypeinterventionalSponsorZakria MowafyRan2019 to 2020Enrolled60ConditionsHypertrophic ScarsArmscryotherapy (Gymna Cryoflow ICE-CT), Exercising, Positioning and splinting, Pressure Therapy and Massage
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 10 syntheses or guidelines pooled it, 363 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Silicone gel sheeting for treating keloid scars.The Cochrane database of systematic reviews · 2023
    Pooled it
  6. Silicone gel sheeting for treating hypertrophic scars.The Cochrane database of systematic reviews · 2021
    Pooled it
  7. Evidence-based therapy in hypertrophic scars: An update of a systematic review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Interventions for acne scars.The Cochrane database of systematic reviews · 2016
    Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Review of the 100 Most Cited Articles inEuropean burn journal · 2025
    Review

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Anna I ArnoRoss Tilley Burn Centre and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada; Plastic Surgery Department and Burn Unit, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.
Gerd G GauglitzDepartment of Dermatology and Allergology, Ludwig Maximilians University, Munich, Germany.
Juan P BarretPlastic Surgery Department and Burn Unit, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.
Marc G JeschkeRoss Tilley Burn Centre and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address: marc.jeschke@sunnybrook.ca.
Health Sciences Centre · CALudwig-Maximilians-Universität München · DEUniversitat Autònoma de Barcelona · ES

Funding

Hepatic ER stress contributes to morbidity and mortality after burn injury.R01GM087285 · NIGMS · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI BOEHNING, DARREN F, JESCHKE, MARC GERHARD · 2010 to 2018
$1.9M
NIGMS NIH HHS R01 GM087285NIGMS NIH HHS R01 GM087285-01
6 · The paper itself

Abstract

Keloids and hypertrophic scars occur anywhere from 30 to 90% of patients, and are characterized by pathologically excessive dermal fibrosis and aberrant wound healing. Both entities have different clinical and histochemical characteristics, and unfortunately still represent a great challenge for clinicians due to lack of efficacious treatments. Current advances in molecular biology and genetics reveal new preventive and therapeutical options which represent a hope to manage this highly prevalent, chronic and disabling problem, with long-term beneficial outcomes and improvement of quality of life. While we wait for these translational clinical products to be marketed, however, it is imperative to know the basics of the currently existing wide array of strategies to deal with excessive scars: from the classical corticotherapy, to the most recent botulinum toxin and lasers. The main aim of this review paper is to offer a useful up-to-date guideline to prevent and treat keloids and hypertrophic scars.

Indexed as

Adjuvants, ImmunologicAdrenal Cortex HormonesAminoquinolinesAnti-Inflammatory AgentsAntineoplastic AgentsBleomycinBotulinum Toxins, Type ACicatrix, HypertrophicCryotherapyDisease ManagementFluorouracilHumansImiquimodInjections, IntralesionalInterferonsKeloidAdjuvants, ImmunologicAdrenal Cortex HormonesAminoquinolinesAnti-Inflammatory AgentsAntineoplastic AgentsBleomycinBotulinum Toxins, Type AFluorouracilImiquimodInterferonsNeuromuscular Agentsortho-AminobenzoatestranilastCorticoidsCriotherapyKeloidLaserReviewScar

Identifiers

PMID24767715
PMCPMC4186912
OpenAlexW2045647435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.