Evidence map›Paper›PMID 24767210›Full record

ArticlePigment cell & melanoma research2014

Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A.

Hun-Way Hwang, Laura L Baxter, Stacie K Loftus, Julia C Cronin, Niraj S Trivedi, Bhavesh Borate, William J Pavan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pigment cell & melanoma research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. MicroRNA-452: a double-edged sword in multiple human cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Reciprocal regulations between miRNAs and HIF-1α in human cancers.Cellular and molecular life sciences : CMLS · 2019
    Review
  18. Article
  19. Article
  20. MicroRNA-Directed Cancer Therapies: Implications in Melanoma Intervention.The Journal of pharmacology and experimental therapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hun-Way HwangGenetic Disease Research Branch, Department of Health and Human Services, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Laura L Baxter
Stacie K Loftus
Julia C Cronin
Niraj S Trivedi
Bhavesh Borate
William J Pavan
National Human Genome Research Institute · USNational Institutes of Health · US

Funding

Function genomic analysis of neural crest developmentZIAHG000136 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PAVAN, WILLIAM J · 2009 to 2023
$13.6M
ANALYSIS OF DOMINANT MEGACOLON--ANOTHER MODEL FORHIRSCHSPRUNG DISEASEZIAHG000070 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI PAVAN, WILLIAM J · 2009 to 2023
$13.4M
Intramural NIH HHS ZIA HG000070
6 · The paper itself

Abstract

The complex genetic changes underlying metastatic melanoma need to be deciphered to develop new and effective therapeutics. Previously, genome-wide microarray analyses of human melanoma identified two reciprocal gene expression programs, including transcripts regulated by either transforming growth factor, beta 1 (TGFβ1) pathways, or microphthalmia-associated transcription factor (MITF)/SRY-box containing gene 10 (SOX10) pathways. We extended this knowledge by discovering that melanoma cell lines with these two expression programs exhibit distinctive microRNA (miRNA) expression patterns. We also demonstrated that hypoxia-inducible factor 1 alpha (HIF1A) is increased in TGFβ1 pathway-expressing melanoma cells and that HIF1A upregulates miR-210, miR-218, miR-224, and miR-452. Reduced expression of these four miRNAs in TGFβ1 pathway-expressing melanoma cells arrests the cell cycle, while their overexpression in mouse melanoma cells increases the expression of the hypoxic response gene Bnip3. Taken together, these data suggest that HIF1A may regulate some of the gene expression and biological behavior of TGFβ1 pathway-expressing melanoma cells, in part via alterations in these four miRNAs.

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticAnimalsCell CycleCell Line, TumorCluster AnalysisGenomeHumansHypoxia-Inducible Factor 1, alpha SubunitMelanomaMembrane ProteinsMiceMicrophthalmia-Associated Transcription FactorMicroRNAsMitochondrial ProteinsOligonucleotide Array Sequence AnalysisBNip3 protein, mouseHIF1A protein, humanHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsMicrophthalmia-Associated Transcription FactorMicroRNAsMIRN210 microRNA, humanMIRN218 microRNA, humanMIRN224 microRNA, humanMIRN452 microRNA, humanMITF protein, humanMitf protein, mouseMitochondrial ProteinsTransforming Growth Factor beta1Bnip3HIF1hypoxiamelanomamiRNA

Identifiers

PMID24767210
PMCPMC4150815
OpenAlexW2069359362

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.