ArticleJournal of affective disorders2014
Increased fear-potentiated startle in major depressive disorder patients with lifetime history of suicide attempt.
Article in Journal of affective disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- The dynamic interplay between anxiety-related, psychotic, and suicidal experiences: a qualitative study.BMC psychiatry · 2025Trial
- Magnetoencephalography biomarkers of suicide attempt history and antidepressant response to ketamine in treatment-resistant major depression.Journal of affective disorders · 2022Trial
- The novel vasopressin receptor (V1aR) antagonist SRX246 reduces anxiety in an experimental model in humans: a randomized proof-of-concept study.Psychopharmacology · 2021Trial
- Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety.Journal of psychiatric research · 2014Trial
- Selective orexin receptor cross-over treatment increases resilience and expression of neuroplastic signaling genes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Impact of behavioral inhibitory control and startle reactivity to uncertain threat on youth suicide risk.Psychophysiology · 2025Article
- Toward objective characterizations of suicide risk: A narrative review of laboratory-based cognitive and behavioral tasks.Neuroscience and biobehavioral reviews · 2023Review
- History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- The Dynamic Relationship Between Alpha and Beta Power and Next-Day Suicidal Ideation in Individuals With Treatment-Resistant Depression.Biological psychiatry global open science · 2022Article
- Distinguishing veterans with suicidal ideation from suicide attempt history: The role of emotion reactivity.Suicide & life-threatening behavior · 2021Article
- The neural correlates of low social integration as a risk factor for suicide.European archives of psychiatry and clinical neuroscience · 2020Article
- Candidate Biomarkers of Suicide Crisis Syndrome: What to Test Next? A Concept Paper.The international journal of neuropsychopharmacology · 2020Review
- Startle during threat longitudinally predicts functional impairment independent of DSM diagnoses.Psychiatry research · 2019Article
- Familial Aggregation and Coaggregation of Suicide Attempts and Comorbid Mental Disorders in Adults.JAMA psychiatry · 2019Article
- Interactions of immediate and long-term action regulation in the course and complications of bipolar disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts.Frontiers in psychiatry · 2019Article
- Exercise decreases defensive responses to unpredictable, but not predictable, threat.Depression and anxiety · 2018Article
- If or when? Uncertainty's role in anxious anticipation.Psychophysiology · 2018Article
- Startling Differences: Using the Acoustic Startle Response to Study Sex Differences and Neurosteroids in Affective Disorders.Current psychiatry reports · 2018Review
- Understanding Suicide Risk within the Research Domain Criteria (RDoC) Framework: Insights, Challenges, and Future Research Considerations.Clinical psychological science : a journal of the Association for Psychological Science · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSuicide is a common reason for psychiatric emergency and morbidity, with few effective treatments. Anxiety symptoms have emerged as potential modifiable risk factors in the time before a suicide attempt, but few studies have been conducted using laboratory measures of fear and anxiety. We operationally defined fear and anxiety as increased startle reactivity during anticipation of predictable (fear-potentiated startle) and unpredictable (anxiety-potentiated startle) shock. We hypothesized that a lifetime history of suicide attempt (as compared to history of no suicide attempt) would be associated with increased fear-potentiated startle.
methodsA post-hoc analysis of fear- and anxiety-potentiated startle was conducted in 28 medication-free patients with Major Depressive Disorder (MDD) divided according to suicide attempt history.
resultsThe magnitude of fear-potentiated startle was increased in depressed patients with lifetime suicide attempts compared to those without a lifetime history of suicide attempt (F(1,26)=5.629, p=.025). There was no difference in anxiety-potentiated startle by suicide attempt history. LIMITATIONS: This is a post-hoc analysis of previously analyzed patient data from a study of depressed inpatients. Further replication of the finding with a larger patient sample is indicated.
conclusionsIncreased fear-potentiated startle in suicide attempters suggests the role of amygdala in depressed patients with a suicide attempt history. Findings highlight the importance of anxiety symptoms in the treatment of patients at increased suicide risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.