ArticleCell2014
Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors.
Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 206 citations in OpenAlex.
- Social Context Alters Chemical Signalling and Endocrine Profiles in Two Mouse Subspecies.Journal of chemical ecology · 2026Article
- Article
- Male and female mice scent mark during social communication regardless of sexual motivation or partner identity.Cell reports · 2026Article
- Sex and Individual Specificity in Behavioral Responses to Chemical Communication and Urinary Volatile Components in Captive Forest Musk Deer (Animals : an open access journal from MDPI · 2026Article
- Bile acid chemosensation in mammals supports species and gut microbiome evaluation.bioRxiv : the preprint server for biology · 2026Article
- Kirrel3 homophilic adhesion function is required for male-directed aggression and vomeronasal acuity to urine chemosignals.Frontiers in cellular neuroscience · 2026Article
- Review
- Combinatorial responsiveness of chemosensory neurons in mouse explants revealed by DynamicNeuroTracker.Cell reports methods · 2025Article
- A high-fiber diet mimics aging-related signatures of caloric restriction in mammals.Nature communications · 2025Article
- SST neurons in the periaqueductal gray regulate urination and bladder function.Communications biology · 2025Article
- Regularity, variability, and individuality: urine marking patterns of male mice toward stimuli representing varying degrees of kinship.Chemical senses · 2025Article
- Behavioral Assays in the Study of Olfaction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Airway sensory systems: breathing new life into microbiota-brain communication.Frontiers in cellular neuroscience · 2025Review
- Chronic high-dose testosterone disrupts social cognition and enhances social dominance in male long-Evans rats.Hormones and behavior · 2024Article
- Sex-specific discrimination of familiar and unfamiliar mates in the Tokay gecko.Animal cognition · 2024Article
- Species recognition and the divergences in the chemical and ultrasonic signals between two coexistingCurrent zoology · 2024Article
- Article
- Sexual discrimination and attraction through scents in the water vole, Arvicola terrestris.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Type 2 vomeronasal receptor-A4 subfamily: Potential predator sensors in mice.Genesis (New York, N.Y. : 2000) · 2024Review
- CFA-treated mice induce hyperalgesia in healthy mice via an olfactory mechanism.European journal of pain (London, England) · 2024Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
During social interactions, an individual's behavior is largely governed by the subset of signals emitted by others. Discrimination of "self" from "other" regulates the territorial urine countermarking behavior of mice. To identify the cues for this social discrimination and understand how they are interpreted, we designed an olfactory-dependent countermarking assay. We find major urinary proteins (MUPs) sufficient to elicit countermarking, and unlike other vomeronasal ligands that are detected by specifically tuned sensory neurons, MUPs are detected by a combinatorial strategy. A chemosensory signature of "self" that modulates behavior is developed via experience through exposure to a repertoire of MUPs. In contrast, aggression can be elicited by MUPs in an experience-independent but context-dependent manner. These findings reveal that individually emitted chemical cues can be interpreted based on their combinatorial permutation and relative ratios, and they can transmit both fixed and learned information to promote multiple behaviors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.