ArticleBMC biotechnology2014
A novel self-assembled oligopeptide amphiphile for biomimetic mineralization of enamel.
Article in BMC biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Caries Management with Non-Metallic Nanomaterials: A Systematic Review.International journal of nanomedicine · 2022Pooled it
- Applications of Nanomaterials in Restorative Dentistry and Endodontics: A Narrative Review.Materials (Basel, Switzerland) · 2026Review
- CaAm-P19: a novel amelogenin-derived peptide for enamel remineralization.Regenerative biomaterials · 2026Article
- Synthetic extracellular matrices with function-encoding peptides.Nature reviews bioengineering · 2023Review
- Peptides in Dentistry: A Scoping Review.Bioengineering (Basel, Switzerland) · 2023Article
- Efficacy of the dual-action GA-KR12 peptide for remineralising initial enamel caries: an in vitro study.Clinical oral investigations · 2022Article
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Biomimetic mineralisation systems for in situ enamel restoration inspired by amelogenesis.Journal of materials science. Materials in medicine · 2021Review
- Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration.Bio-design and manufacturing · 2021Review
- Bioinspired multifunctional adhesive system for next generation bio-additively designed dental restorations.Journal of the mechanical behavior of biomedical materials · 2021Review
- Biomimetic Aspects of Oral and Dentofacial Regeneration.Biomimetics (Basel, Switzerland) · 2020Review
- Challenges of Engineering Biomimetic Dental and Paradental Tissues.Tissue engineering and regenerative medicine · 2020Review
- Remineralization of enamel caries by an amelogenin-derived peptide and fluorideRegenerative biomaterials · 2020Article
- The Significance and Utilisation of Biomimetic and Bioinspired Strategies in the Field of Biomedical Material Engineering: The Case of Calcium Phosphat-Protein Template Constructs.Materials (Basel, Switzerland) · 2020Review
- Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms.Molecular oral microbiology · 2019Review
- Effect of biomimetic mineralization on enamel and dentin: A Raman and EDX analysis.Dental materials : official publication of the Academy of Dental Materials · 2019Article
- Repair of dentine-related lesions without a drill or injection.RSC advances · 2019Article
- Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite.Gels (Basel, Switzerland) · 2019Review
- Enamel biomimetics-fiction or future of dentistry.International journal of oral science · 2019Review
- Regenerating a monoblock to obturate root canalsvia a mineralising strategy.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearchers are looking for biomimetic mineralization of ena/mel to manage dental erosion. This study evaluated biomimetic mineralization of demineralized enamel induced by a synthetic and self-assembled oligopeptide amphiphile (OPA).
resultsThe results showed that the OPA self-assembled into nano-fibres in the presence of calcium ions and in neutral acidity. The OPA was alternately immersed in calcium chloride and sodium hypophosphate solutions to evaluate its property of mineralization. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) showed nucleation and growth of amorphous calcium phosphate along the self-assembled OPA nano-fibres when it was repetitively exposed to solutions with calcium and phosphate ions. Energy dispersive spectrometry (EDS) confirmed that these nano-particles contained calcium and phosphate. Furthermore, electron diffraction pattern suggested that the nano-particles precipitated on OPA nano-fibres were comparable to amorphous calcium phosphate. Acid-etched human enamel slices were incubated at 37°C in metastable calcium phosphate solution with the OPA for biomimetic mineralization. SEM and X-ray diffraction indicated that the OPA induced the formation of hydroxyapatite crystals in organized bundles on etched enamel. TEM micrographs revealed there were 20-30 nm nano-amorphous calcium phosphate precipitates in the biomimetic mineralizing solution. The particles were found separately bound to the oligopeptide fibres. Biomimetic mineralization with or without the oligopeptide increased demineralized enamel microhardness.
conclusionsA novel OPA was successfully fabricated, which fostered the biomimetic mineralization of demineralized enamel. It is one of the primary steps towards the design and construction of novel biomaterial for future clinical therapy of dental erosion.
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