Trial reportJournal of studies on alcohol and drugs2014
Predictors of pretreatment commitment to abstinence: results from the COMBINE study.
Trial report in Journal of studies on alcohol and drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta-regression analysis to develop an enrichment strategy.Alcoholism, clinical and experimental research · 2021Pooled it
- World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom.Addiction (Abingdon, England) · 2020Trial
- Drink goal difficulty effect on outcomes in moderation-based alcohol treatment for sexual minority men.Journal of substance abuse treatment · 2020Trial
- Maintenance of World Health Organization Risk Drinking Level Reductions and Posttreatment Functioning Following a Large Alcohol Use Disorder Clinical Trial.Alcoholism, clinical and experimental research · 2019Trial
- Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Trial
- Drinking goals and attainment in a naltrexone trial of young adult heavy drinkers.Journal of consulting and clinical psychology · 2018Trial
- Readiness to change is a predictor of reduced substance use involvement: findings from a randomized controlled trial of patients attending South African emergency departments.BMC psychiatry · 2016Trial
- Methamphetamine Use, Post-Traumatic Stress, and Substance Use Consequences Among American Indians with a Substance Use Problem.Substance use & misuse · 2026Article
- Change in substance use among patients in opioid maintenance treatment: baseline to 1-year follow-up.Harm reduction journal · 2024Article
- Using machine learning to examine predictors of treatment goal change among individuals seeking treatment for alcohol use disorder.Journal of substance abuse treatment · 2022Article
- SF-6D utility scores for alcohol use disorder status and alcohol consumption risk levels in the US population.Addiction (Abingdon, England) · 2021Article
- Factors associated with quality of life trajectories among inpatients treated for alcohol use disorders: A prospective cohort study.Addictive behaviors reports · 2020Article
- Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.Alcoholism, clinical and experimental research · 2020Article
- Prevention, screening, and treatment for heavy drinking and alcohol use disorder.The lancet. Psychiatry · 2019Review
- Reduction in non-abstinent World Health Organization (WHO) drinking risk levels and drug use disorders: 3-year follow-up results in the US general population.Drug and alcohol dependence · 2019Article
- Reduction in non-abstinent WHO drinking risk levels and depression/anxiety disorders: 3-year follow-up results in the US general population.Drug and alcohol dependence · 2019Article
- Reduction in Nonabstinent WHO Drinking Risk Levels and Change in Risk for Liver Disease and Positive AUDIT-C Scores: Prospective 3-Year Follow-Up Results in the U.S. General Population.Alcoholism, clinical and experimental research · 2018Article
- Alcohol treatment goal choice predicts longitudinal drinking outcomes in adolescent substance users.Journal of child & adolescent substance abuse · 2018Article
- Change in non-abstinent WHO drinking risk levels and alcohol dependence: a 3 year follow-up study in the US general population.The lancet. Psychiatry · 2017Article
- Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models.Addiction biology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectivePatients entering treatment for alcohol problems do not have uniform treatment goals, and a pretreatment drinking goal has a significant impact on treatment outcome. The objective of this study was to understand better how an array of individual characteristics, including factors that affect treatment, are related to treatment goals before beginning alcohol treatment in the COMBINE (Combining Medications and Behavioral Interventions) Study.
methodParticipants were alcohol-dependent individuals (N = 1,156; 357 women) recruited at 11 outpatient academic alcoholism-treatment clinics across the United States to participate in a randomized, double-blind, placebo-controlled trial that combined behavioral intervention with acamprosate and/or naltrexone. Treatment goal was coded as controlled drinking, conditional abstinence, or total abstinence. Multinomial logistic regressions assessed whether there were significant relationships between predictor variables and pretreatment goal selection.
resultsLower levels of alcohol-related consequences, lower readiness to change, higher family income, more daily drinkers in social network, and lack of prior treatment or Alcoholics Anonymous engagement predicted choice of a controlled drinking goal over a total abstinence goal. Fewer alcohol-related consequences, lower readiness to change, and more daily drinkers in-network predicted choice of a conditional abstinence goal over a total abstinence goal.
conclusionsHigher levels of functioning, lower levels of consequences, no prior involvement in treatment and Alcoholics Anonymous, and a more drinking-saturated social environment are associated with the choice of a non-abstinence goal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.