ArticleInternational journal of experimental pathology2014
A potential link among antioxidant enzymes, histopathology and trace elements in canine visceral leishmaniasis.
Article in International journal of experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Leishmaniasis and Trace Element Alterations: a Systematic Review.Biological trace element research · 2021Pooled it
- Histomorphometric Evaluation of Subchronic and Chronic Effects of Novel Experimental Calcium Aluminate- and Calcium Silicate-Based Dental Cement Materials on Rat Liver, Kidney, Brain, and Spleen Tissues.Journal of functional biomaterials · 2026Article
- Canine Visceral Leishmaniasis: A Histological and Immunohistochemical Study of Fibropoiesis in Chronic Interstitial Pneumonitis.Microorganisms · 2024Article
- Comparative Study of Colorimetric In Situ Hybridization and Quantitative Real-Time Polymerase Chain Reaction for Diagnosis of Infection byTropical medicine and infectious disease · 2024Article
- The Interaction of Zinc as an Essential Trace Element withAdvanced biomedical research · 2024Review
- Zinc and Manganese Imbalances in BALB/c Mice Experimentally Infected with Leishmania (Leishmania) amazonensis.Acta parasitologica · 2023Article
- Humoral and Cellular Immune Response in Asymptomatic Dogs with Visceral Leishmaniasis: A Review.Vaccines · 2022Review
- Selenium and protozoan parasitic infections: selenocompounds and selenoproteins potential.Parasitology research · 2022Review
- Vitamins A and D and Zinc Affect the Leshmanicidal Activity of Canine Spleen Leukocytes.Animals : an open access journal from MDPI · 2021Article
- Selenium and Dogs: A Systematic Review.Animals : an open access journal from MDPI · 2021Review
- Redox Status in Canine Leishmaniasis.Animals : an open access journal from MDPI · 2021Article
- Article
- Nutritional status and vitamin A and zinc levels in patients with kala-azar in Piauí, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Article
- ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs.Journal of veterinary internal medicine · 2019Article
- Meglumine Antimoniate (Glucantime) Causes Oxidative Stress-Derived DNA Damage in BALB/c Mice Infected by Leishmania (Leishmania) infantum.Antimicrobial agents and chemotherapy · 2017Article
- Library of Seleno-Compounds as Novel Agents against Leishmania Species.Antimicrobial agents and chemotherapy · 2017Article
- Occurrence of Leishmania infantum and associated histological alterations in the genital tract and mammary glands of naturally infected dogs.Parasitology research · 2016Article
- Immunohistochemical study of hepatic fibropoiesis associated with canine visceral leishmaniasis.International journal of experimental pathology · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine visceral leishmaniasis (CVL) is a severe and fatal systemic chronic inflammatory disease. We investigated the alterations in, and potential associations among, antioxidant enzymes, trace elements and histopathology in CVL. Blood and tissue levels of Cu-Zn superoxide dismutase, catalase and glutathione peroxidase were measured in mixed-breed dogs naturally infected with Leishmania infantum chagasi, symptomatic (n = 19) and asymptomatic (n = 11). Serum levels of copper, iron, zinc, selenium and nitric oxide, and plasma lipid peroxidation were measured. Histological and morphometric analyses were conducted of lesions in liver, spleen and lymph nodes. We found lower blood catalase and glutathione peroxidase activity to be correlated with lower iron and selenium respectively. However, higher activity of Cu-Zn superoxide dismutase was not correlated with the increase in copper and decreased in zinc observed in infected animals compared to controls. Organ tissue was characterized by lower enzyme activity in infected dogs than in controls, but this was not correlated with trace elements. Lipid peroxidation was higher in symptomatic than in asymptomatic and control dogs and was associated with lesions such as chronic inflammatory reaction, congestion, haemosiderin and fibrosis. Systemic iron deposition was observed primarily in the symptomatic dogs showing a higher tissue parasite load. Dogs with symptomatic CVL displayed enhanced LPO and Fe tissue deposition associated with decreased levels of antioxidant enzymes. These results showed new points in the pathology of CVL and might open new treatment perspectives associated with antioxidants and the role of iron in the pathogenesis of CVL.
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