ArticleThe European journal of neuroscience2014
Region- and domain-dependent action of nomifensine.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum.Analytical and bioanalytical chemistry · 2021Article
- Molecular fMRI of Serotonin Transport.Neuron · 2016Article
- Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum.Neuropharmacology · 2016Article
- Kinetic diversity of dopamine transmission in the dorsal striatum.Journal of neurochemistry · 2015Article
- A novel restricted diffusion model of evoked dopamine.ACS chemical neuroscience · 2014Review
- Ethanol-Induced Taurine Elevation in the Rat Dorsal Striatum.Advances in experimental medicine and biologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The dopamine (DA) terminal fields in the rat dorsal striatum (DS) and nucleus accumbens core (NAcc) are organized as patchworks of domains that exhibit distinct kinetics of DA release and clearance. The present study used fast-scan cyclic voltammetry recordings of electrically evoked DA overflow to test the hypothesis that nomifensine might exhibit domain-dependent actions within the NAcc, as we previously found to be the case within the DS. Within the NAcc, nomifensine preferentially enhanced evoked DA overflow in the slow domains compared with the fast domains. To seek a kinetic explanation for nomifensine's selective actions, we quantified the apparent KM of DA clearance by numerically evaluating the derivative of the descending phase of the DA signal after the end of the stimulus. For comparison, we likewise quantified the apparent KM in the domains of the DS. As expected, because it is a competitive inhibitor, nomifensine significantly increased the apparent KM in both the fast and slow domains of both the NAcc and DS. However, our analysis also led to the novel finding that nomifensine preferentially increases the apparent KM in the NAcc compared with the DS; the apparent KM increased by ~500% in the NAcc and by ~200% in the DS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.