ArticleFood & nutrition research2014
In vitro catabolism of quercetin by human fecal bacteria and the antioxidant capacity of its catabolites.
Article in Food & nutrition research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Quercetin's antitumor effect in bladder cancer: Synergistic regulation of gut microbiota and l-serine metabolic pathway.Acta pharmaceutica Sinica. B · 2026Article
- The Intestinal Fate of Phenolic Substances in Honey: Metabolism by Gut Microbiota, Regulation of Bioavailability, and Its Prebiotic Effects on Host Health.Foods (Basel, Switzerland) · 2026Review
- Low Brain Levels of Dietary Polyphenols and Their Conjugates: Reassessing Mechanisms of Alzheimer's Disease Prevention.Journal of dementia and alzheimer's disease · 2026Article
- In Vitro Fermentation of Green Tea by Human Gut Microbiota Enhances Bioactivity and Bidirectionally Modulates Polyphenol Metabolites and Gut Microbiota.Foods (Basel, Switzerland) · 2026Article
- Anti-Cancer Effects of Quercetin: What Role Does the Gut Microbiota Play?Molecules (Basel, Switzerland) · 2026Review
- Identification of Novel Metabolic Signatures on Human Gut Microbiota: Ellagic Acid, Naringenin, and Phloroglucinol.International journal of molecular sciences · 2025Article
- Plant-Derived Nutraceuticals in Mental Health and Brain Function: Mechanisms of Action and Therapeutic Potential.International journal of molecular sciences · 2025Review
- New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation.Journal of pharmaceutical analysis · 2024Review
- Flavonoids, gut microbiota, and host lipid metabolism.Engineering in life sciences · 2024Review
- Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability.International journal of molecular sciences · 2023Article
- The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline.Antioxidants (Basel, Switzerland) · 2023Review
- Dietary phytochemicals, gut microbiota composition, and health outcomes in human and animal models.Bioscience of microbiota, food and health · 2023Review
- Phytonutrients: Sources, bioavailability, interaction with gut microbiota, and their impacts on human health.Frontiers in nutrition · 2022Review
- Microbial Flavonoid Metabolism: A Cardiometabolic Disease Perspective.Annual review of nutrition · 2021Article
- Review
- Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further.Frontiers in nutrition · 2021Review
- Changes in the Serum Metabolome of Patients Treated With Broad-Spectrum Antibiotics.Pathogens & immunity · 2020Article
- Plasma quercetin metabolites are affected by intestinal microbiota of human microbiota-associated mice fed with a quercetin-containing diet.Journal of clinical biochemistry and nutrition · 2019Article
- Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols.Molecules (Basel, Switzerland) · 2019Review
- An Integrated View of the Effects of Wine Polyphenols and Their Relevant Metabolites on Gut and Host Health.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPart of quercetin flows into the colon after escaping the absorption of the small intestine and will be degraded by colonic microbiota. The catabolites in the colon partially determine the physiological activity of quercetin.
methodsSeven gut bacteria isolated from human feces were utilized to in vitro ferment quercetin. Their catabolites were analyzed with high-performance liquid chromatography and mass spectrometry, and the antioxidant activities of their fermented broths were compared with that of quercetin.
resultsOne metabolite, 3,4-dihydroxyphenylacetic acid, was produced by both C. perfringens and B. fragilis transforming quercetin. No other metabolites were detected in the other fermented broths. The antioxidant activities of all strains fermenting quercetin reached the highest values at the concentration of 1 mg/mL quercetin in broth; the fermented products of C. perfringens and B. fragilis presented stronger activities than those of other strains at most concentrations of quercetin in broth. Additionally, all of the fermented broths presented a decline of the antioxidant activities compared to quercetin. Therefore, the antioxidant activity of quercetin will be lost when it reaches the human colon because of the gut bacterial fermentation.
conclusionsThis is the first study to report that quercetin can be degraded by C. perfringens and B. fragilis and transformed to the same metabolite, 3,4-dihydroxyphenylacetic acid, and that antioxidant activities decline when quercetin is fermented by seven gut bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.