ArticleAdvanced synthesis & catalysis2014
A General and Practical Palladium-Catalyzed Direct α-Arylation of Amides with Aryl Halides.
Article in Advanced synthesis & catalysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Tandem C(spAdvanced synthesis & catalysis · 2016Article
- Palladium-Catalyzed α-Arylation of Methyl Sulfonamides with Aryl Chlorides.Advanced synthesis & catalysis · 2016Article
- Palladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols.Organic letters · 2016Article
- Chemoselective Palladium-Catalyzed Deprotonative Arylation/[1,2]-Wittig Rearrangement of Pyridylmethyl Ethers.Chemical science · 2016Article
- Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines.Organic letters · 2015Article
- Synthesis of (diarylmethyl)amines using Ni-catalyzed arylation of C(spChemical science · 2015Article
- Palladium-catalyzed α-arylation of aryl acetic acid derivatives via dienolate intermediates with aryl chlorides and bromides.Organic letters · 2015Article
- Reversed-Polarity Synthesis of Diaryl Ketones through Palladium-Catalyzed Direct Arylation of 2-Aryl-1,3-dithianes.Advanced synthesis & catalysis · 2014Article
- Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides.Chemical communications (Cambridge, England) · 2014Article
- NiXantphos: a deprotonatable ligand for room-temperature palladium-catalyzed cross-couplings of aryl chlorides.Journal of the American Chemical Society · 2014Article
- Palladium-catalyzed α-arylation of benzylic phosphonates.Organic letters · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong's indole-based phosphine ligand and provides monoarylated amides in up to 95% yield. Excellent chemoselectivities (>10:1) in the mono- and diarylation with aryl bromides were achieved by careful selection of bases, solvents, and stoichiometry. Under the coupling conditions, the weakly acidic α-protons of amides (p
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