Evidence map›Paper›PMID 24764681›Full record

ArticleWorld journal of gastroenterology2014

Caspase-3 expression in metastatic lymph nodes of esophageal squamous cell carcinoma is prognostic of survival.

Xiu-Shen Wang, Kong-Jia Luo, Amos Ela Bella, Shan-Shan Bu, Jing Wen, Shui-Shen Zhang, Yi Hu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiu-Shen WangXiu-Shen Wang, Shan-Shan Bu, Department of Radiation Oncology, Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
Kong-Jia LuoXiu-Shen Wang, Shan-Shan Bu, Department of Radiation Oncology, Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
Amos Ela BellaXiu-Shen Wang, Shan-Shan Bu, Department of Radiation Oncology, Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
Shan-Shan BuXiu-Shen Wang, Shan-Shan Bu, Department of Radiation Oncology, Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
Jing WenXiu-Shen Wang, Shan-Shan Bu, Department of Radiation Oncology, Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
Shui-Shen ZhangXiu-Shen Wang, Shan-Shan Bu, Department of Radiation Oncology, Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
Yi HuXiu-Shen Wang, Shan-Shan Bu, Department of Radiation Oncology, Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China.
Henan Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess whether differential expression of caspase-3 in paired metastatic lymph nodes (LNs) is prognostic of survival in patients with resectable esophageal squamous cell carcinoma (ESCC).

methodsCapases-3 expression was evaluated immunohistochemically in 122 pairs of primary ESCCs and regional metastatic LNs assembled on tissue microarrays. The impact of caspase-3 expression on survival outcomes was analyzed by the Kaplan-Meier method and Cox proportional hazards regression model.

resultsThe level of caspase-3 expression was significantly higher in LN metastases than in primary tumors (P < 0.001). Caspase-3 expression in the primary tumors was associated with longer median survival (23 mo vs 21 mo, P = 0.033), whereas higher expression in paired metastatic LNs was associated with shorter median survival (20 mo vs 22 mo, P = 0.043). Multivariate analysis showed that both were independent prognostic factors.

conclusionCaspase-3 expression in metastatic LNs may be a potential independent predictor of poorer overall survival in patients with resected ESCC and LN metastasis. Protein expression in metastatic tumors may be a biomarker prognostic of survival.

Indexed as

AdultAgedBiomarkers, TumorCarcinoma, Squamous CellCaspase 3Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansImmunohistochemistryKaplan-Meier EstimateLymphatic MetastasisLymph NodesMaleBiomarkers, TumorCASP3 protein, humanCaspase 3Caspase-3 proteinEsophageal squamous cell carcinomaLymph nodePrognosis

Identifiers

PMID24764681
PMCPMC3989979
OpenAlexW1979969311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.