ArticleWorld journal of gastroenterology2014
Case-control study of factors that trigger inflammatory bowel disease flares.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Prognostic tools for identification of high risk in people with Crohn's disease: systematic review and cost-effectiveness study.Health technology assessment (Winchester, England) · 2021Pooled it
- Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation.Alimentary pharmacology & therapeutics · 2018Pooled it
- Incidence ofFrontiers in pediatrics · 2026Article
- Ultra-high altitude environment triggers life-threatening gastrointestinal bleeding in undiagnosed Crohn's disease: a case report.Frontiers in medicine · 2026Article
- The Bidirectional Effects of Periodontal Disease and Oral Dysbiosis on Gut Inflammation in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2025Observational
- Factors contributing to flares of ulcerative colitis in North India- a case-control study.BMC gastroenterology · 2023Article
- Information and Communication Technologies in Patients With Immune-Mediated Inflammatory Diseases: Cross-sectional Survey.Journal of medical Internet research · 2022Article
- Clinical factors to predict flare-up in patients with inflammatory bowel disease during international air travel: A prospective study.PloS one · 2022Article
- A Practical Clinical Approach to the Management of High-Risk Ulcerative Colitis.Gastroenterology & hepatology · 2021Article
- Impact of Digital Health Monitoring in the Management of Inflammatory Bowel Disease.Journal of medical systems · 2021Article
- Digital Health Apps in the Clinical Care of Inflammatory Bowel Disease: Scoping Review.Journal of medical Internet research · 2019Article
- The Influence of Antidepressants on the Disease Course Among Patients With Crohn's Disease and Ulcerative Colitis-A Danish Nationwide Register-Based Cohort Study.Inflammatory bowel diseases · 2019Article
- The Frequency of Clinic Visits Was Not Associated with Medication Adherence or Outcome in Children with Inflammatory Bowel Diseases.Canadian journal of gastroenterology & hepatology · 2018Article
- Impact of Treatment-Related Beliefs on Medication Adherence in Immune-Mediated Inflammatory Diseases: Results of the Global ALIGN Study.Advances in therapy · 2017Article
- Gut Bacterial DNA Translocation is an Independent Risk Factor of Flare at Short Term in Patients With Crohn's Disease.The American journal of gastroenterology · 2016Observational
- Budesonide Multi-matrix for the Treatment of Patients with Ulcerative Colitis.Digestive diseases and sciences · 2016Review
- Influence of environmental factors on the onset and course of inflammatory bowel disease.World journal of gastroenterology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the association between inflammatory bowel diseases (IBD) flares and potential triggers.
methodsPatients evaluated for an acute flare of IBD by a gastroenterologist at the Dallas VA Medical Center were invited to participate, as were a control group of patients with IBD in remission. Patients were systematically queried about nonsteroidal anti-inflammatory drug use, antibiotic use, stressful life events, cigarette smoking, medication adherence, infections, and travel in the preceding 3 mo. Disease activity scores were calculated for each patient at the time of enrollment and each patient's chart was reviewed. Multivariate regression analysis was performed.
resultsA total of 134 patients with IBD (63 with Crohn's disease, 70 with ulcerative colitis, and 1 with indeterminate colitis) were enrolled; 66 patients had flares of their IBD and 68 were controls with IBD in remission (for Crohn's patients, average Crohn's disease activity index was 350 for flares vs 69 in the controls; for UC patients, Mayo score was 7.6 for flares vs 1 for controls in those with full Mayo available and 5.4p for flares vs 0.1p for controls in those with partial Mayo score). Only medication non-adherence was significantly more frequent in the flare group than in the control group (48.5% vs 29.4%, P = 0.03) and remained significant on multivariate analysis (OR = 2.86, 95%CI: 1.33-6.18). On multivariate regression analysis, immunomodulator use was found to be associated with significantly lower rates of flare (OR = 0.40, 95%CI: 0.19-0.86).
conclusionIn a study of potential triggers for IBD flares, medication non-adherence was significantly associated with flares. These findings are incentive to improve medication adherence.
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