Evidence map›Paper›PMID 24764661›Full record

ReviewWorld journal of gastroenterology2014

Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer.

Jung Ho Kim, Gyeong Hoon Kang

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02781337 (Epidemiological and Molecular Colorectal Cancer Registry), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02781337 recruitingnot on this map

Epidemiological and Molecular Colorectal Cancer Registry

Typeobservational_patient_registrySponsorHospital Italiano de Buenos AiresRan2012 to 2033Enrolled2,100ConditionsColorectal Neoplasms, Colorectal Cancer
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jung Ho KimJung Ho Kim, Department of Pathology, SMG-SNU Boramae Medical Center, Seoul 156-707, South Korea.
Gyeong Hoon KangJung Ho Kim, Department of Pathology, SMG-SNU Boramae Medical Center, Seoul 156-707, South Korea.
SNUH SMG-SNU Boramae Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancers (CRCs) with a high level of microsatellite instability (MSI-H) are clinicopathologically distinct tumors characterized by predominance in females, proximal colonic localization, poor differentiation, mucinous histology, tumor-infiltrating lymphocytes, a Crohn's-like lymphoid reaction and a favorable prognosis. In terms of their molecular features, MSI-H CRCs are heterogeneous tumors associated with various genetic and epigenetic alterations, including DNA mismatch repair deficiency, target microsatellite mutations, BRAF mutations, a CpG island methylator phenotype-high (CIMP-H) status, and a low level of genomic hypomethylation. The molecular heterogeneity of MSI-H CRCs also depends on ethnic differences; for example, in Eastern Asian countries, relatively low frequencies of CIMP-H and BRAF mutations have been observed in MSI-H CRCs compared to Western countries. Although the prognostic features of MSI-H CRCs include a favorable survival of patients and low benefit of adjuvant chemotherapy, there may be prognostic differences based on the molecular heterogeneity of MSI-H CRCs. Here, we have reviewed and discussed the molecular and prognostic features of MSI-H CRCs, as well as several putative prognostic or predictive molecular markers, including HSP110 expression, beta2-microglobulin mutations, myosin 1a expression, CDX2/CK20 expression, SMAD4 expression, CIMP status and LINE-1 methylation levels.

Indexed as

Gene Expression Regulation, NeoplasticMicrosatellite InstabilityMutationCDX2 Transcription FactorCell DifferentiationColorectal NeoplasmsCpG IslandsDNA MethylationDNA RepairEpigenesis, GeneticGerm-Line MutationHomeodomain ProteinsHumansLong Interspersed Nucleotide ElementsMicrosatellite RepeatsPhenotypeBRAF protein, humanCDX2 protein, humanCDX2 Transcription FactorHomeodomain ProteinsKRAS protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)ras ProteinsSmad4 ProteinSMAD4 protein, humanAdjuvant chemotherapyColorectal cancerCpG islandsDNA methylationDNA mismatch repairMicrosatellite instabilityPrognosis

Identifiers

PMID24764661
PMCPMC3989959
OpenAlexW1993928295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.