ReviewExtreme physiology & medicine2014
Frostbite: a practical approach to hospital management.
Review in Extreme physiology & medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05555602 (Clinical Observation of the Comfort and Efficacy of Carbon Dioxide), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Observation of the Comfort and Efficacy of Carbon Dioxide(CO2) Laser 10,600 nm Combined With Cold-air Cooling Device Zimmer Cryo 6 for Burn Scars or Linear Scars.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Interventions for frostbite injuries.The Cochrane database of systematic reviews · 2020Pooled it
- Botulinum Toxin A in the treatment of frostbite sequelae - results from a blinded, early-phase, comparative trial.International journal of circumpolar health · 2023Trial
- Frostbite: diagnosis, treatment, prognosis, and future directions.Military Medical Research · 2026Review
- Clinical course and management of extremity frostbite in populations under forced movement in border regions.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Synthesis of Protocols for Frostbite Care From the FROST Study Sites.Journal of burn care & research : official publication of the American Burn Association · 2026Observational
- Causes and Consequences of Freezing Cold Injuries in the Norwegian Armed Forces from the Soldier's Perspective-A Qualitative Study.International journal of environmental research and public health · 2026Article
- Time to Thrombolytics and Tissue Salvage: Assessing Response Following Severe Frostbite Injury.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Can iloprost be used for treatment of cold weather injury at the point of wounding in a forward operating environment? A literature review.International journal of circumpolar health · 2023Review
- The classification of freezing cold injuries - a NATO research task group position paper.International journal of circumpolar health · 2023Review
- Freezing cold injuries among soldiers in the Norwegian Armed Forces - A cross sectional study.International journal of circumpolar health · 2023Article
- Analysis of wound types and wound care methods after the 2023 Kahramanmaras earthquake.Joint diseases and related surgery · 2023Article
- Bone scintigraphy outperformed anatomic images in frostbite injuries: a case report.European journal of hybrid imaging · 2022Article
- Frostbite in hot climates of Central Asia: retrospective analysis of the microflora of wound and antibiotic therapy.International journal of burns and trauma · 2022Article
- Article
- Long-Term Sequelae of Frostbite-A Scoping Review.International journal of environmental research and public health · 2021Article
- Use of fluorescence to visualize response to iloprost treatment for frostbite.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Article
- Onychalgia Causes and Mechanisms: The "GIFTED KID" and the "FOMITE".Skin appendage disorders · 2020Review
- Article
- Frostbite injuries and our experience treatment in the Samarkand area Uzbekistan.International journal of burns and trauma · 2020Article
- The utility of bone scintigraphy with SPECT/CT in the evaluation and management of frostbite injuries.The British journal of radiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frostbite presentation to hospital is relatively infrequent, and the optimal management of the more severely injured patient requires a multidisciplinary integration of specialist care. Clinicians with an interest in wilderness medicine/freezing cold injury have the awareness of specific potential interventions but may lack the skill or experience to implement the knowledge. The on-call specialist clinician (vascular, general surgery, orthopaedic, plastic surgeon or interventional radiologist), who is likely to receive these patients, may have the skill and knowledge to administer potentially limb-saving intervention but may be unaware of the available treatment options for frostbite. Over the last 10 years, frostbite management has improved with clear guidelines and management protocols available for both the medically trained and winter sports enthusiasts. Many specialist surgeons are unaware that patients with severe frostbite injuries presenting within 24 h of the injury may be good candidates for treatment with either TPA or iloprost. In this review, we aim to give a brief overview of field frostbite care and a practical guide to the hospital management of frostbite with a stepwise approach to thrombolysis and prostacyclin administration for clinicians.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.