ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2014
Influence of aromatase inhibition on the bone-protective effects of testosterone.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Gonadal steroid-dependent effects on bone turnover and bone mineral density in men.The Journal of clinical investigation · 2016Trial
- Passive bicycle training stimulates epiphyseal bone formation and restores bone integrity independent of locomotor recovery in a rat spinal cord injury model.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury.Journal of neuroscience research · 2020Article
- Diet-induced Generalized Periodontitis in Lewis Rats.Comparative medicine · 2019Article
- Potential therapeutic use of relaxin in accelerating closure of cranial bone defects in mice.Physiological reports · 2019Article
- Zoledronate treatment duration is linked to bisphosphonate-related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis.Oral diseases · 2019Article
- Stanozolol promotes osteogenic gene expression and apposition of bone mineral in vitro.Journal of applied oral science : revista FOB · 2018Article
- Article
- Testosterone Plus Finasteride Prevents Bone Loss without Prostate Growth in a Rodent Spinal Cord Injury Model.Journal of neurotrauma · 2017Article
- Article
- Testosterone and Adult Male Bone: Actions Independent of 5α-Reductase and Aromatase.Exercise and sport sciences reviews · 2015Review
- Injection of testosterone may be safer and more effective than transdermal administration for combating loss of muscle and bone in older men.American journal of physiology. Endocrinology and metabolism · 2015Review
- Sclerostin inhibition prevents spinal cord injury-induced cancellous bone loss.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Sex steroid actions in male bone.Endocrine reviews · 2014Review
- Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy.In vivo (Athens, Greece)Article
- The Current Understanding of Sarcopenia: Emerging Tools and Interventional Possibilities.American journal of lifestyle medicineReview
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
The influence of the aromatase enzyme in androgen-induced bone maintenance after skeletal maturity remains somewhat unclear. Our purpose was to determine whether aromatase activity is essential to androgen-induced bone maintenance. Ten-month-old male Fisher 344 rats (n = 73) were randomly assigned to receive Sham surgery, orchiectomy (ORX), ORX + anastrozole (AN; aromatase inhibitor), ORX + testosterone-enanthate (TE, 7.0 mg/wk), ORX + TE + AN, ORX + trenbolone-enanthate (TREN; nonaromatizable, nonestrogenic testosterone analogue; 1.0 mg/wk), or ORX + TREN + AN. ORX animals exhibited histomorphometric indices of high-turnover osteopenia and reduced cancellous bone volume compared with Shams. Both TE and TREN administration suppressed cancellous bone turnover similarly and fully prevented ORX-induced cancellous bone loss. TE- and TREN-treated animals also exhibited greater femoral neck shear strength than ORX animals. AN co-administration slightly inhibited the suppression of bone resorption in TE-treated animals but did not alter TE-induced suppression of bone formation or the osteogenic effects of this androgen. In TREN-treated animals, AN co-administration produced no discernible effects on cancellous bone turnover or bone volume. ORX animals also exhibited reduced levator ani/bulbocavernosus (LABC) muscle mass and elevated visceral adiposity. In contrast, TE and TREN produced potent myotrophic effects in the LABC muscle and maintained fat mass at the level of Shams. AN co-administration did not alter androgen-induced effects on muscle or fat. In conclusion, androgens are able to induce direct effects on musculoskeletal and adipose tissue, independent of aromatase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.