ArticleEuropean journal of nuclear medicine and molecular imaging2014
Cost-effectiveness of preoperative SPECT/CT combined with lymphoscintigraphy vs. lymphoscintigraphy for sentinel lymph node excision in patients with cutaneous malignant melanoma.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Cost-Effectiveness of Drug Treatments for Advanced Melanoma: A Systematic Literature Review.PharmacoEconomics · 2017Pooled it
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- New EAU/ASCO guideline recommendations on sentinel node biopsy for penile cancer and remaining challenges from a nuclear medicine perspective.European journal of nuclear medicine and molecular imaging · 2024Article
- Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts.International journal of molecular sciences · 2023Review
- Methods of Sentinel Lymph Node Identification in Auricular Melanoma.Plastic and reconstructive surgery. Global open · 2021Article
- Comparison ofJournal of clinical medicine · 2020Review
- Imaging of pediatric cutaneous melanoma.Pediatric radiology · 2019Review
- Article
- Melanoma & nuclear medicine: new insights & advances.Melanoma management · 2018Review
- Investigating the role of SPECT/CT in dynamic sentinel lymph node biopsy for penile cancers.European journal of nuclear medicine and molecular imaging · 2017Article
- Comparison of Single-Photon Emission Computed Tomography-Computed Tomography (SPECT/CT) and Conventional Planar Lymphoscintigraphy for Sentinel Node Localization in Patients with Cutaneous Malignancies.Annals of surgical oncology · 2017Article
- Comprehensive cost analysis of sentinel node biopsy in solid head and neck tumors using a time-driven activity-based costing approach.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Prediction of positron emission tomography/computed tomography (PET/CT) positivity in patients with high-risk primary melanoma.American journal of nuclear medicine and molecular imaging · 2016Article
- EANM practice guidelines for lymphoscintigraphy and sentinel lymph node biopsy in melanoma.European journal of nuclear medicine and molecular imaging · 2015Article
- Demonstrating the benefits of clinical nuclear imaging: is it time to add economic analysis?European journal of nuclear medicine and molecular imaging · 2014Article
- Advantages of Sentinel Lymph Node Mapping by Single Photon Emission Computed Tomography/Computed Tomography in Early-Stage Malignant Head-and-Neck Skin Tumors.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeMalignant melanoma has become a major growing interdisciplinary problem in public health worldwide. Sentinel lymph node excision (SLNE) in conjunction with preoperative SPECT/CT is considered the most sensitive and specific staging test for the detection of micrometastatic melanoma in regional lymph nodes. Among patients with clinically lymph node-negative melanoma, the use of SPECT/CT-aided SLNE compared with SLNE alone has been found to be associated with a higher frequency of metastatic involvement and a higher rate of disease-free survival. The aim of this study was to analyse the cost-effectiveness of SLNE with preoperative SPECT/CT for detecting sentinel lymph nodes versus that of standard SLNE with preoperative lymphoscintigraphy from a single-institution database.
methodsCost-effectiveness analysis of two surgical approaches for SLNE for malignant melanoma at the University Hospital Essen, Skin Cancer Center in Essen, Germany. Between March 2003 and April 2011 464 patients eligible for SLNE were identified . Of these patients, 403 with clinically negative lymph nodes who underwent SLNE with or without preoperative SPECT/CT qualified for subsequent analysis.
resultsBetween March 2003 and October 2008, 254 patients were operated upon with the standard technique. From November 2008, 149 patients underwent the SPECT/CT technique. Cost analysis showed a mean cost saving of <euro> 710.50 when SPECT/CT was added to preoperative imaging. This was achieved by a reduction in operative time (median, Q1;Q3, 40 min, 40;50 min, vs. 45 min, 35;60 min; p = 0.002), hospital stay duration (5 days, 3;8 days, vs. 8 days, 4.5;14.5 days; p < 0.001) and more frequent use of local anaesthesia (90.6 % vs. 70.5 %; p < 0.001). The median cost of SLNE using SPECT/CT was <euro> 1,619.7 (Q1;Q3 <euro> 1,317.0;2,603.4) and of SLNE without SPECT/CT was <euro> 2,330.2 (<euro> 1,468.3;4,058.1; p < 0.001), a cost saving of 30.5 %.
conclusionIn patients with cutaneous melanoma, the use of preoperative SPECT/CT-aided SLNE compared with standard SLNE was associated not only with higher detection of metastatic involvement but also with a significant cost reduction.
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