Trial reportEuropean journal of nuclear medicine and molecular imaging2014
Characterizing IgG4-related disease with ¹⁸F-FDG PET/CT: a prospective cohort study.
Trial report in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 234 citations in OpenAlex.
- European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations.United European gastroenterology journal · 2020Guideline
- Immunoglobulin G4-related hypertrophic pachymeningitis: A case-oriented review.Neurology(R) neuroimmunology & neuroinflammation · 2019Pooled it
- IgG4-related disease: a systematic review of this unrecognized disease in pediatrics.Pediatric rheumatology online journal · 2016Pooled it
- IgG4-related orbital disease - An update.Indian journal of ophthalmology · 2026Review
- Article
- Proof-of-concept study: longitudinal immune biomarker signatures in treatment-naïve IgG4-related disease.Scientific reports · 2026Article
- Complete Treatment Response of Isolated Lacrimal IgG4-Related Disease onMolecular imaging and radionuclide therapy · 2026Article
- A Rare Presentation of Acute Cholecystitis Mimicking Malignancy in a Young Male With Elevated IgG4.Cureus · 2026Article
- A case of an immunoglobulin G4 related inflammatory pseudotumor involving the clivus and the nasopharynx: A challenging case of a perplexing entity with an exhaustive overview.Brain & spine · 2026Article
- IgG4-related sclerosing cholangitis: navigating diagnostic dilemmas and the challenge of relapse.Frontiers in medicine · 2026Review
- Does adjunctive endoscopic biliary drainage improve outcomes beyond glucocorticoids alone in IgG4-related pancreatobiliary disease?BMC gastroenterology · 2025Article
- Unraveling the complexity of IgG4-related aortitis and periarteritis: from pathogenesis to clinical practice.Frontiers in immunology · 2025Review
- IgG4-related disease - focus on digestive system involvement.Frontiers in immunology · 2025Review
- A 69-year-old man with generalised lymphadenopathy, glandular swelling and pleural effusion.Breathe (Sheffield, England) · 2025Article
- IgG4-Related Lymphadenopathy Mimicking Mediastinal Lymph Node Metastasis of Lung Cancer onDiagnostics (Basel, Switzerland) · 2024Article
- Comparative Analysis of Classification Criteria in IgG4-Related Disease and Evaluating Diagnostic Accuracy from a Retrospective Cohort in Clinical Practice.Diagnostics (Basel, Switzerland) · 2024Article
- [Application ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Volume-Based Quantitative Measurement of [Molecular imaging and biology · 2024Article
- Emerging multimodality imaging techniques for the pulmonary circulation.The European respiratory journal · 2024Review
- Appropriate timing to perform an interimAnnals of hematology · 2024Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIgG4-related disease (IgG4-RD) is an increasingly recognized clinicopathological disorder with immune-mediated inflammatory lesions mimicking malignancies. A cohort study was prospectively designed to investigate the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in characterizing IgG4-RD.
methodsThirty-five patients diagnosed with IgG4-RD according to the consensus criteria were enrolled with informed consent. All patients underwent baseline (18)F-FDG PET/CT evaluation. Among them, 29 patients underwent a second (18)F-FDG PET/CT scan after 2 to 4 weeks of steroid-based therapy.
resultsAll 35 patients were found with (18)F-FDG-avid hypermetabolic lesion(s); 97.1% (34/35) of these patients showed multi-organ involvement. Among the 35 patients, 71.4% (25/35) patients were found with more organ involvement on (18)F-FDG PET/CT than conventional evaluations including physical examination, ultrasonography, and computed tomography (CT). (18)F-FDG PET/CT demonstrated specific image characteristics and pattern of IgG4-RD, including diffusely elevated (18)F-FDG uptake in the pancreas and salivary glands, patchy lesions in the retroperitoneal region and vascular wall, and multi-organ involvement that cannot be interpreted as metastasis. Comprehensive understanding of all involvement aided the biopsy-site selection in seven patients and the recanalization of ureteral obstruction in five patients. After 2 to 4 weeks of steroid-based therapy at 40 mg to 50 mg prednisone per day, 72.4% (21/29) of the patients showed complete remission, whereas the others exhibited > 81.8% decrease in (18)F-FDG uptake.
conclusionF-FDG PET/CT is a useful tool for assessing organ involvement, monitoring therapeutic response, and guiding interventional treatment of IgG4-RD. The image pattern is suggested to be updated into the consensus diagnostic criteria for IgG4-RD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.