ArticleLab on a chip2014
3D printed microfluidic devices with integrated versatile and reusable electrodes.
Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed, 285 citations in OpenAlex.
- Review of Materials for Engineering and Design of 3D-Printed Electrochemical Sensors.Electrochimica acta · 2026Article
- Xanthine determination in food samples using a carbon veil-based bi-enzyme amperometric sensor.Mikrochimica acta · 2026Article
- Portable electrochemiluminescent detection system with 3D printed materials and mobile phone detection.Talanta open · 2025Article
- 3D Printed Transwell Microfluidic Devices for Epithelial Cell Culture with Shear Stress.ACS measurement science au · 2025Article
- 3D-Printed Microfluidic-Based Cell Culture System With Analysis to Investigate Macrophage Activation.Electrophoresis · 2025Article
- 3D printed microfluidic devices with electrodes for electrochemical analysis.Analytical methods : advancing methods and applications · 2024Review
- Use of 3D printing to integrate microchip electrophoresis with amperometric detection.Analytical and bioanalytical chemistry · 2024Article
- Demonstration of a Transparent and Adhesive Sealing Top for Microfluidic Lab-Chip Applications.Sensors (Basel, Switzerland) · 2024Article
- A 3D printed sheath flow interface for surface enhanced Raman spectroscopy (SERS) detection in flow.The Analyst · 2024Article
- Additive Manufacturing Applications in Biosensors Technologies.Biosensors · 2024Review
- Unlocking the potential of 3D printed microfluidics for mass spectrometry analysis using liquid infused surfaces.Analytica chimica acta · 2023Article
- Characterization of PDMS Microchannels Using Horizontally or Vertically Formed 3D-Printed Molds by Digital Light Projection.ACS omega · 2023Article
- Planar carbon electrodes for real-time quantification of hydrogen sulfide release from cells.Sensors & diagnostics · 2023Article
- Article
- PDMS Organ-On-Chip Design and Fabrication: Strategies for Improving Fluidic Integration and Chip Robustness of Rapidly Prototyped Microfluidic In Vitro Models.Micromachines · 2022Article
- Three-Dimensional Printing and Its Potential to Develop Sensors for Cancer with Improved Performance.Biosensors · 2022Review
- A 3D-printed, multi-modal microfluidic device for measuring nitric oxide and ATP release from flowing red blood cells.Analytical methods : advancing methods and applications · 2022Article
- 3D-printed electrochemical platform with multi-purpose carbon black sensing electrodes.Mikrochimica acta · 2022Article
- Evaluation and optimization of PolyJet 3D-printed materials for cell culture studies.Analytical and bioanalytical chemistry · 2022Article
- PolyJet-Based 3D Printing against Micromolds to Produce Channel Structures for Microchip Electrophoresis.ACS omega · 2022Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
We report two 3D printed devices that can be used for electrochemical detection. In both cases, the electrode is housed in commercially available, polymer-based fittings so that the various electrode materials (platinum, platinum black, carbon, gold, silver) can be easily added to a threaded receiving port printed on the device; this enables a module-like approach to the experimental design, where the electrodes are removable and can be easily repolished for reuse after exposure to biological samples. The first printed device represents a microfluidic platform with a 500 × 500 μm channel and a threaded receiving port to allow integration of either polyetheretherketone (PEEK) nut-encased glassy carbon or platinum black (Pt-black) electrodes for dopamine and nitric oxide (NO) detection, respectively. The embedded 1 mm glassy carbon electrode had a limit of detection (LOD) of 500 nM for dopamine and a linear response (R(2) = 0.99) for concentrations between 25-500 μM. When the glassy carbon electrode was coated with 0.05% Nafion, significant exclusion of nitrite was observed when compared to signal obtained from equimolar injections of dopamine. When using flow injection analysis with a Pt/Pt-black electrode and standards derived from NO gas, a linear correlation (R(2) = 0.99) over a wide range of concentrations (7.6-190 μM) was obtained, with the LOD for NO being 1 μM. The second application showcases a 3D printed fluidic device that allows collection of the biologically relevant analyte adenosine triphosphate (ATP) while simultaneously measuring the release stimulus (reduced oxygen concentration). The hypoxic sample (4.8 ± 0.5 ppm oxygen) released 2.4 ± 0.4 times more ATP than the normoxic sample (8.4 ± 0.6 ppm oxygen). Importantly, the results reported here verify the reproducible and transferable nature of using 3D printing as a fabrication technique, as devices and electrodes were moved between labs multiple times during completion of the study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.