ArticlePloS one2014
Loss of function of endothelin-2 leads to reduced ovulation and CL formation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha.Nutrients · 2023Review
- A novel missense variant in endothelin-2 (EDN2) causes a growth and respiratory lethal syndrome in bovine.Animal genetics · 2022Article
- Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina.Disease models & mechanisms · 2021Article
- Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women.International journal of molecular sciences · 2021Article
- Role of RGMc as a Neogenin Ligand in Follicular Development in the Ovary.Biomedicines · 2021Article
- Comparative gene expression profiling of mouse ovaries upon stimulation with natural equine chorionic gonadotropin (N-eCG) and tethered recombinant-eCG (R-eCG).BMC biotechnology · 2020Article
- The EDN2 rs110287192 gene polymorphism is associated with paratuberculosis susceptibility in multibreed cattle population.PloS one · 2020Article
- Ovulation: Parallels With Inflammatory Processes.Endocrine reviews · 2019Review
- Core Binding Factor β Expression in Ovarian Granulosa Cells Is Essential for Female Fertility.Endocrinology · 2018Article
- Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure.BMC nephrology · 2017Article
- Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture.Scientific reports · 2017Article
- Genome-wide association study of aggressive behaviour in chicken.Scientific reports · 2016Article
- Core Binding Factor-β Knockdown Alters Ovarian Gene Expression and Function in the Mouse.Molecular endocrinology (Baltimore, Md.) · 2016Article
- In vivo imaging reveals an essential role of vasoconstriction in rupture of the ovarian follicle at ovulation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Chemokine Ligand 20: A Signal for Leukocyte Recruitment During Human Ovulation?Endocrinology · 2015Article
- Generation and characterization of an endothelin-2 iCre mouse.Genesis (New York, N.Y. : 2000) · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Endothelin-2 (EDN2), a potent vasoconstrictive peptide, is transiently produced by periovulatory follicles at the time of ovulation when corpus luteum (CL) formation begins. EDN2 induces contraction of ovarian smooth muscles ex vivo via an endothelin receptor A-mediated pathway. In this study, we aimed to determine if EDN2 is required for normal ovulation and subsequent CL formation in?vivo. In the ovaries of a mouse model that globally lacks the Edn2 gene (Edn2 knockout mouse; Edn2KO), histology showed that post-pubertal Edn2KO mice possess follicles of all developmental stages, but no corpora lutea. When exogenous gonadotropins were injected to induce super-ovulation, Edn2KO mice exhibited significantly impaired ovulation and CL formation compared to control littermates. Edn2KO ovaries that did ovulate in response to gonadotropins did not contain histologically and functionally identifiable CL. Intra-ovarian injection of EDN2 peptide results suggest partial induction of ovulation in Edn2KO mice. Endothelin receptor antagonism in wild type mice similarly disrupted ovulation, CL formation, and progesterone secretion. Overall, this study suggests that EDN2 is necessary for normal ovulation and CL formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.